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AIM33 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854887, updated on 2-Nov-2024

Summary

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Official Symbol
AIM33
Official Full Name
cytochrome-b5 reductase
Primary source
SGD:S000004552
Locus tag
YML087C
See related
AllianceGenome:SGD:S000004552; FungiDB:YML087C; VEuPathDB:YML087C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R1 (cytochrome b5 reductase 1) and CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See AIM33 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (94431..95369, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SCF ubiquitin ligase complex subunit UFO1 Neighboring gene D-arabinono-1,4-lactone oxidase Neighboring gene alpha-tubulin TUB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
  2. The VINE complex is an endosomal VPS9-domain GEF and SNX-BAR coat. Shortill SP, et al. Elife, 2022 Aug 8. PMID 35938928, Free PMC Article
  3. Selective defects in gene expression control genome instability in yeast splicing mutants. Tam AS, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462576, Free PMC Article
  4. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article
  5. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated. Voynova NS, et al. Eukaryot Cell, 2015 Dec. PMID 26432633, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytochrome-b5 reductase
NP_013623.1
  • hypothetical protein, highly conserved across species; homolog of human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss; AIM33 has a paralog, PGA3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    94431..95369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182446.1 → NP_013623.1  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0J6, Q04516
    UniProtKB/TrEMBL
    A6ZLX8, B3LLG9, C7GV72, C8ZEB7
    Conserved Domains (1) summary
    cd06183
    Location:75 → 312
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04516.1

Gene LinkOut

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