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BET5 TRAPP subunit BET5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854898, updated on 2-Nov-2024

Summary

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Official Symbol
BET5
Official Full Name
TRAPP subunit BET5
Primary source
SGD:S000004542
Locus tag
YML077W
See related
AllianceGenome:SGD:S000004542; FungiDB:YML077W; VEuPathDB:YML077W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to guanyl-nucleotide exchange factor activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport. Part of TRAPPI protein complex; TRAPPII protein complex; and TRAPPIII protein complex. Used to study cancer and melanoma. Orthologous to human TRAPPC1 (trafficking protein particle complex subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BET5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (111865..112344)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cff1p Neighboring gene peptidylprolyl isomerase CPR3 Neighboring gene War1p Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification of TRAPP from Saccharomyces cerevisiae and identification of its mammalian counterpart. Sacher M, et al. Methods Enzymol, 2001. PMID 11210539
  2. Two antigens recognized by autologous cytolytic T lymphocytes on a melanoma result from a single point mutation in an essential housekeeping gene. Chiari R, et al. Cancer Res, 1999 Nov 15. PMID 10582700
  3. Yeast rab GTPase-activating protein Gyp1p localizes to the Golgi apparatus and is a negative regulator of Ypt1p. Du LL, et al. Mol Biol Cell, 2001 May. PMID 11359917, Free PMC Article
  4. TRAPP stimulates guanine nucleotide exchange on Ypt1p. Wang W, et al. J Cell Biol, 2000 Oct 16. PMID 11038176, Free PMC Article
  5. Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Lipatova Z, et al. Genetics, 2016 Nov. PMID 27672095, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
contributes_to guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi vesicle transport IEA
Inferred from Electronic Annotation
more info
  
involved_in autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TRAPP complex IEA
Inferred from Electronic Annotation
more info
  
part_of TRAPPI protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TRAPPIII protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in phagophore assembly site IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TRAPP subunit BET5
NP_013634.1
  • Core component of transport protein particle (TRAPP) complexes I-III; TRAPP complexes are related multimeric guanine nucleotide-exchange factors for the GTPase Ypt1p, regulating ER-Golgi traffic (TRAPPI), intra-Golgi traffic (TRAPPII), endosome-Golgi traffic (TRAPPII and III) and autophagy (TRAPPIII); human homology TRAPPC1 complements yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    111865..112344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182436.1 → NP_013634.1  TPA: TRAPP subunit BET5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013634.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K6, Q03630
    UniProtKB/TrEMBL
    A6ZLY8, B3LLH9, C7GW12, C8ZEC8, G2WJX8, N1P656
    Conserved Domains (1) summary
    cd14855
    Location:4 → 152
    TRAPPC1_MUM2; Trafficking protein particle complex subunit 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03630.1

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