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FPR3 peptidylprolyl isomerase FPR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854901, updated on 2-Nov-2024

Summary

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Official Symbol
FPR3
Official Full Name
peptidylprolyl isomerase FPR3
Primary source
SGD:S000004539
Locus tag
YML074C
See related
AllianceGenome:SGD:S000004539; FungiDB:YML074C; VEuPathDB:YML074C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
NPI46
Summary
Enables macrolide binding activity and peptidyl-prolyl cis-trans isomerase activity. Involved in meiotic recombination checkpoint signaling and nucleosome assembly. Located in nucleolus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See FPR3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (120089..121324, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene War1p Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Neighboring gene ribosomal 60S subunit protein L6A Neighboring gene Tcb3p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast immunophilin Fpr3 is a physiological substrate of the tyrosine-specific phosphoprotein phosphatase Ptp1. Wilson LK, et al. J Biol Chem, 1995 Oct 20. PMID 7559654
  2. Yeast NPI46 encodes a novel prolyl cis-trans isomerase that is located in the nucleolus. Shan X, et al. J Cell Biol, 1994 Aug. PMID 8051210, Free PMC Article
  3. Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription. Park SK, et al. Mol Genet Genomics, 2014 Apr. PMID 24297734
  4. The yeast HtrA orthologue Ynm3 is a protease with chaperone activity that aids survival under heat stress. Padmanabhan N, et al. Mol Biol Cell, 2009 Jan. PMID 18946088, Free PMC Article
  5. The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity. Hochwagen A, et al. Cell, 2005 Sep 23. PMID 16179256

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Report show that Fpr3 regulates Cse4 proteolysis and the structural changes in CSe4 might be important for its interaction with Psh1.
    Title: Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
  2. The results thus provide a further demonstration for the elusive role of Fpr3 and Fpr4 in histone chaperones.
    Title: Nuclear FKBPs, Fpr3 and Fpr4 affect genome-wide genes transcription.
  3. The FK506 binding protein Fpr3 prevents premature adaptation to damage and thus serves to maintain recombination checkpoint activity.
    Title: The FK506 binding protein Fpr3 counteracts protein phosphatase 1 to maintain meiotic recombination checkpoint activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables macrolide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in meiotic recombination checkpoint signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in meiotic recombination checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleosome assembly IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptidylprolyl isomerase FPR3
NP_013637.1
  • Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; affects expression of multiple genes via its role in nucleosome assembly; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; FPR3 has a paralog, FPR4, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    120089..121324 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182433.1 → NP_013637.1  TPA: peptidylprolyl isomerase FPR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013637.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K9, P38911
    UniProtKB/TrEMBL
    G2WJY1, N1NYY3
    Conserved Domains (2) summary
    COG0545
    Location:287 → 410
    FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam17800
    Location:118 → 162
    NPL; Nucleoplasmin-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38911.2

Gene LinkOut

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