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Y' element ATP-dependent helicase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854906, updated on 14-Nov-2024

Summary

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Official Full Name
Y' element ATP-dependent helicase
Primary source
SGD:S000004602
Locus tag
YML133C
See related
AllianceGenome:SGD:S000004602; FungiDB:YML133C; VEuPathDB:YML133C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable helicase activity. Predicted to be involved in telomere maintenance via recombination. Located in mitochondrion. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and primary immunodeficiency disease. Orthologous to human DHX58 (DExH-box helicase 58); RIGI (RNA sensor RIG-I); and IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (461..4684, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Cos3p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element, is induced in survivors defective for telomerase. Yamada M, et al. J Biol Chem, 1998 Dec 11. PMID 9837911
  2. Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Iacovella MG, et al. Nucleic Acids Res, 2018 Sep 6. PMID 30011030, Free PMC Article
  3. Analysis of the TORC1 interactome reveals a spatially distinct function of TORC1 in mRNP complexes. Chang Y, et al. J Cell Biol, 2021 Apr 5. PMID 33566094, Free PMC Article
  4. An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain. Ranjitkar P, et al. Mol Cell, 2010 Nov 12. PMID 21070971, Free PMC Article
  5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. Bowman S, et al. Nature, 1997 May 29. PMID 9169872

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H2AZ histone chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent H3-H4 histone complex chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables chromatin extrusion motor activity IEA
Inferred from Electronic Annotation
more info
  
enables cohesin loader activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables forked DNA-dependent helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables four-way junction helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded 3'-5' DNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin looping IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance via recombination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Y' element ATP-dependent helicase
NP_013573.1
  • Putative Y' element ATP-dependent helicase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    461..4684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182496.1 → NP_013573.1  TPA: Y' element ATP-dependent helicase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013573.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXU4, D6W0F2, Q03099, Q12054, Q99208
    Conserved Domains (1) summary
    COG0513
    Location:314 → 830
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03099.1

Gene LinkOut

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