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NGL3 3'-5' poly(A) RNA exonuclease [ Saccharomyces cerevisiae S288C ]

Gene ID: 854921, updated on 18-Sep-2024

Summary

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Official Symbol
NGL3
Official Full Name
3'-5' poly(A) RNA exonuclease
Primary source
SGD:S000004587
Locus tag
YML118W
See related
AllianceGenome:SGD:S000004587; FungiDB:YML118W; VEuPathDB:YML118W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables poly(A)-specific ribonuclease activity. Involved in polyadenylation-dependent RNA catabolic process. Orthologous to several human genes including NOCT (nocturnin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See NGL3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (32334..33851)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene NADH-ubiquinone reductase (H(+)-translocating) NDI1 Neighboring gene uncharacterized protein Neighboring gene Nab6p Neighboring gene borate transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases. Feddersen A, et al. Nucleic Acids Res, 2012 Jan. PMID 21965533, Free PMC Article
  2. Ngl2p is a Ccr4p-like RNA nuclease essential for the final step in 3'-end processing of 5.8S rRNA in Saccharomyces cerevisiae. Faber AW, et al. RNA, 2002 Sep. PMID 12358428, Free PMC Article
  3. Identification of four families of yCCR4- and Mg2+-dependent endonuclease-related proteins in higher eukaryotes, and characterization of orthologs of yCCR4 with a conserved leucine-rich repeat essential for hCAF1/hPOP2 binding. Dupressoir A, et al. BMC Genomics, 2001. PMID 11747467, Free PMC Article
  4. Recruitment of Rpd3 to the telomere depends on the protein arginine methyltransferase Hmt1. Milliman EJ, et al. PLoS One, 2012. PMID 22953000, Free PMC Article
  5. Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis. Vizeacoumar FJ, et al. J Cell Biol, 2010 Jan 11. PMID 20065090, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ngl3p is a functional 3'-5' exonuclease most active at slightly acidic conditions.
    Title: Saccharomyces cerevisiae Ngl3p is an active 3'-5' exonuclease with a specificity towards poly-A RNA reminiscent of cellular deadenylases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(A)-specific ribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A)-specific ribonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in polyadenylation-dependent RNA catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
3'-5' poly(A) RNA exonuclease
NP_013588.1
  • 3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p; NGL3 has a paralog, NGL2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    32334..33851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182481.1 → NP_013588.1  TPA: 3'-5' poly(A) RNA exonuclease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013588.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0G6, Q03210, Q03733
    UniProtKB/TrEMBL
    A6ZLU6, B3LLE1, C7GVA0, C8ZE84, N1P5B4
    Conserved Domains (1) summary
    COG5239
    Location:67 → 496
    CCR4; mRNA deadenylase, 3'-5' endonuclease subunit Ccr4 [RNA processing and modification]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03210.1

Gene LinkOut

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