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VAN1 Van1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854925, updated on 2-Nov-2024

Summary

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Official Symbol
VAN1
Official Full Name
Van1p
Primary source
SGD:S000004583
Locus tag
YML115C
See related
AllianceGenome:SGD:S000004583; FungiDB:YML115C; VEuPathDB:YML115C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
LDB13; VRG7; VRG8
Summary
Contributes to alpha-1,6-mannosyltransferase activity. Involved in cell wall mannoprotein biosynthetic process and protein N-linked glycosylation. Part of mannan polymerase complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See VAN1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (40187..41794, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Nab6p Neighboring gene borate transporter Neighboring gene Taf8p Neighboring gene Dat1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Localization of the FAR3 gene: genetic mapping and molecular cloning using a chromosome walk-'n'-roll strategy. Horecka J. Yeast, 1995 Jun 15. PMID 7483842
  2. Sodium orthovanadate-resistant mutants of Saccharomyces cerevisiae show defects in Golgi-mediated protein glycosylation, sporulation and detergent resistance. Kanik-Ennulat C, et al. Genetics, 1995 Jul. PMID 7672592, Free PMC Article
  3. Vanadate-resistant mutants of Saccharomyces cerevisiae show alterations in protein phosphorylation and growth control. Kanik-Ennulat C, et al. Mol Cell Biol, 1990 Mar. PMID 2137555, Free PMC Article
  4. Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis. Striebeck A, et al. Open Biol, 2013 Sep 11. PMID 24026536, Free PMC Article
  5. The components of the Saccharomyces cerevisiae mannosyltransferase complex M-Pol I have distinct functions in mannan synthesis. Stolz J, et al. J Biol Chem, 2002 Nov 22. PMID 12235155

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results provide further information on the role of M-Pol I and its subunits Mnn9 and Van1 in mannan biosynthesis.
    Title: Expression and purification of recombinant M-Pol I from Saccharomyces cerevisiae with alpha-1,6 mannosylpolymerase activity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to alpha-1,6-mannosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell wall mannoprotein biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell wall mannoprotein biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mannan polymerase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mannan polymerase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Van1p
NP_013592.1
  • Component of the mannan polymerase I; complex contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    40187..41794 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182477.1 → NP_013592.1  TPA: Van1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013592.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0G9, P23642
    UniProtKB/TrEMBL
    A6ZLU9, B3LLE4, C7GV97, C8ZE88, G2WJU1, N1NY78
    Conserved Domains (1) summary
    pfam03452
    Location:171 → 480
    Anp1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23642.3

Gene LinkOut

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