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DAT1 Dat1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854927, updated on 18-Sep-2024

Summary

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Official Symbol
DAT1
Official Full Name
Dat1p
Primary source
SGD:S000004581
Locus tag
YML113W
See related
AllianceGenome:SGD:S000004581; FungiDB:YML113W; VEuPathDB:YML113W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DAT1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (44045..44791)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Van1p Neighboring gene Taf8p Neighboring gene Ctk3p Neighboring gene ubiquitin-ubiquitin ligase BUL2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Poly(dA.dT) sequences exist as rigid DNA structures in nucleosome-free yeast promoters in vivo. Suter B, et al. Nucleic Acids Res, 2000 Nov 1. PMID 11058103, Free PMC Article
  2. DNA binding properties of the Saccharomyces cerevisiae DAT1 gene product. Reardon BJ, et al. Nucleic Acids Res, 1995 Dec 11. PMID 8532535, Free PMC Article
  3. A peptide motif that recognizes A.T tracts in DNA. Reardon BJ, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248247, Free PMC Article
  4. Poly(dA:dT), a ubiquitous promoter element that stimulates transcription via its intrinsic DNA structure. Iyer V, et al. EMBO J, 1995 Jun 1. PMID 7781610, Free PMC Article
  5. A DNA binding protein that recognizes oligo(dA).oligo(dT) tracts. Winter E, et al. EMBO J, 1989 Jun. PMID 2670564, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables minor groove of adenine-thymine-rich DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Dat1p
NP_013594.1
  • DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; relocalizes to the cytosol in response to hypoxia; not essential for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    44045..44791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182475.1 → NP_013594.1  TPA: Dat1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013594.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H1, P13483
    UniProtKB/TrEMBL
    C7GV95, G2WJU3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13483.1

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