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ITT1 RBR-type E3 ubiquitin transferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854934, updated on 2-Nov-2024

Summary

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Official Symbol
ITT1
Official Full Name
RBR-type E3 ubiquitin transferase
Primary source
SGD:S000004533
Locus tag
YML068W
See related
AllianceGenome:SGD:S000004533; FungiDB:YML068W; VEuPathDB:YML068W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Involved in regulation of translational termination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human RNF14 (ring finger protein 14). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ITT1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (137550..138944)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene dihydroxyacetone kinase Neighboring gene FACT complex subunit POB3 Neighboring gene Erv41p Neighboring gene Sma2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Itt1p, a novel protein inhibiting translation termination in Saccharomyces cerevisiae. Urakov VN, et al. BMC Mol Biol, 2001. PMID 11570975, Free PMC Article
  2. TRIADs: a new class of proteins with a novel cysteine-rich signature. van der Reijden BA, et al. Protein Sci, 1999 Jul. PMID 10422847, Free PMC Article
  3. tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Studte P, et al. Mol Microbiol, 2008 Sep. PMID 18657261
  4. The role of N-terminal domain of translational release factor eRF3 for the control of functionality and stability in S. cerevisiae. Kodama H, et al. Genes Cells, 2007 May. PMID 17535254
  5. Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast. Moteshareie H, et al. PLoS One, 2018. PMID 30231023, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This study reports on the finding of two genes, ITT1, an inhibitor of translation termination, and RPS1A, a small ribosomal protein, that when deleted yeast cells exhibit similar metal sensitivity phenotypes to gene deletion strain for URE2.
    Title: Heavy metal sensitivities of gene deletion strains for ITT1 and RPS1A connect their activities to the expression of URE2, a key gene involved in metal detoxification in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translational termination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RBR-type E3 ubiquitin transferase
NP_013643.1
  • Protein that modulates the efficiency of translation termination; interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    137550..138944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182427.1 → NP_013643.1  TPA: RBR-type E3 ubiquitin transferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013643.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZA5, Q04638
    UniProtKB/TrEMBL
    G2WJY7
    Conserved Domains (3) summary
    smart00647
    Location:272 → 334
    IBR; In Between Ring fingers
    cd16551
    Location:179 → 233
    RING-HC_RNF169; RING finger, HC subclass, found in RING finger protein 169 (RNF169) and similar proteins
    pfam01485
    Location:385 → 433
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04638.1

Gene LinkOut

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