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MFT1 Mft1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854940, updated on 2-Nov-2024

Summary

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Official Symbol
MFT1
Official Full Name
Mft1p
Primary source
SGD:S000004527
Locus tag
YML062C
See related
AllianceGenome:SGD:S000004527; FungiDB:YML062C; VEuPathDB:YML062C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MFT52
Summary
Enables molecular adaptor activity and nucleic acid binding activity. Involved in DNA recombination; mRNA export from nucleus; and transcription elongation by RNA polymerase II. Located in chromosome, telomeric region. Part of THO complex part of transcription export complex and nucleoplasmic THO complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MFT1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (147505..148683, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ras family GTPase TEM1 Neighboring gene ribosomal 40S subunit protein S1B Neighboring gene DNA helicase PIF1 Neighboring gene 8-oxoguanine glycosylase OGG1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial protein import: isolation and characterization of the Saccharomyces cerevisiae MFT1 gene. Garrett JM, et al. Mol Gen Genet, 1991 Mar. PMID 2017143
  2. Mft52, an acid-bristle protein in the cytosol that delivers precursor proteins to yeast mitochondria. Cartwright P, et al. J Biol Chem, 1997 Feb 21. PMID 9030606
  3. The protein encoded by the MFT1 gene is a targeting factor for mitochondrial precursor proteins, and not a core ribosomal protein. Beilharz T, et al. FEBS Lett, 1997 Apr 28. PMID 9166903
  4. Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity. Sulaiman AA, et al. Front Genet, 2023. PMID 38283148, Free PMC Article
  5. An hpr1 point mutation that impairs transcription and mRNP biogenesis without increasing recombination. Huertas P, et al. Mol Cell Biol, 2006 Oct. PMID 16908536, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nucleic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription elongation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of THO complex part of transcription export complex IEA
Inferred from Electronic Annotation
more info
  
part_of THO complex part of transcription export complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleoplasmic THO complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mft1p
NP_013649.1
  • Subunit of the THO complex; THO is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    147505..148683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182421.1 → NP_013649.1  TPA: Mft1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZB1, P33441
    UniProtKB/TrEMBL
    A6ZM03, B3LLJ3, B5VP70, C7GVZ8, C8ZEE3, G2WJZ3
    Conserved Domains (1) summary
    pfam05615
    Location:57 → 159
    THOC7; Tho complex subunit 7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33441.1

Gene LinkOut

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