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RCF1 Rcf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854978, updated on 2-Nov-2024

Summary

Official Symbol
RCF1
Official Full Name
Rcf1p
Primary source
SGD:S000004492
Locus tag
YML030W
See related
AllianceGenome:SGD:S000004492; FungiDB:YML030W; VEuPathDB:YML030W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AIM31
Summary
Involved in mitochondrial respirasome assembly and regulation of proton transport. Acts upstream of or within mitochondrial cytochrome c oxidase assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex. Orthologous to several human genes including HIGD2A (HIG1 hypoxia inducible domain family member 2A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See RCF1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (216435..216914)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene recombinase RAD52 Neighboring gene Ndc1p Neighboring gene Usa1p Neighboring gene thioredoxin peroxidase TSA1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
part_of respiratory chain complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Rcf1p
NP_013682.1
  • Cytochrome c oxidase subunit; required for assembly of the Complex III-Complex IV supercomplex, and for assembly of Cox13p and Rcf2p into cytochrome c oxidase; similar to Rcf2p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; required for growth under hypoxic conditions; member of the hypoxia induced gene family; C. elegans and human orthologs are functional in yeast

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    216435..216914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182388.1NP_013682.1  TPA: Rcf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013682.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZM32, B3LLM2, C7GT60, C8ZEH4, D6VZE4, Q03713
    UniProtKB/TrEMBL
    G2WK22, N1P0X8
    Conserved Domains (1) summary
    pfam04588
    Location:3281
    HIG_1_N; Hypoxia induced protein conserved region