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USA1 Usa1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854979, updated on 2-Nov-2024

Summary

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Official Symbol
USA1
Official Full Name
Usa1p
Primary source
SGD:S000004491
Locus tag
YML029W
See related
AllianceGenome:SGD:S000004491; FungiDB:YML029W; VEuPathDB:YML029W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables molecular adaptor activity. Involved in ERAD pathway; mRNA splicing, via spliceosome; and positive regulation of protein autoubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See USA1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (217362..219878)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Ndc1p Neighboring gene Rcf1p Neighboring gene thioredoxin peroxidase TSA1 Neighboring gene Yox1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yos9, a control protein for misfolded glycosylated and non-glycosylated proteins in ERAD. Benitez EM, et al. FEBS Lett, 2011 Oct 3. PMID 21871892
  2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. Carroll SM, et al. J Biol Chem, 2010 Feb 19. PMID 19940128, Free PMC Article
  3. Deep mutational scanning highlights a new role for cytosolic regions in Hrd1 function. Peterson BG, et al. bioRxiv, 2023 Apr 3. PMID 37066402, Free PMC Article
  4. N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates. Zattas D, et al. Mol Biol Cell, 2013 Apr. PMID 23363603, Free PMC Article
  5. Cycles of autoubiquitination and deubiquitination regulate the ERAD ubiquitin ligase Hrd1. Peterson BG, et al. Elife, 2019 Nov 12. PMID 31713515, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Usa1 has two important roles in ERAD substrate ubiquitylation
    Title: Usa1 protein facilitates substrate ubiquitylation through two separate domains.
  2. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
    Title: Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ERAD pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in positive regulation of protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Usa1p
NP_013683.1
  • Scaffold subunit of the Hrd1p ubiquitin ligase; also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    217362..219878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182387.1 → NP_013683.1  TPA: Usa1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013683.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZE5, Q03714
    UniProtKB/TrEMBL
    B3LLM3, B5VP97, C8ZEH5
    Conserved Domains (1) summary
    cl28922
    Location:276 → 341
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03714.1

Gene LinkOut

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