TAP42 Tap42p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TAP42
Official Full Name: Tap42p
Primary source: SGD:S000004630
Locus tag: YMR028W
See related: AllianceGenome:SGD:S000004630; FungiDB:YMR028W; VEuPathDB:YMR028W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable protein phosphatase 2A binding activity. Involved in positive regulation of transcription by RNA polymerase I. Acts upstream of or within regulation of TORC1 signaling. Located in cytosol. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to human IGBP1C (IGBP1 family member C) and IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See TAP42 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (327482..328582)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that Tec1 protein stability is under control of the nutrient-sensitive target of rapamycin complex 1 (TORC1) signaling pathway via the Tip41-Tap42-Sit4 branch.
Title: The TEA transcription factor Tec1 links TOR and MAPK pathways to coordinate yeast development.
These data support a model in which autophagy is negatively regulated by the Tap42-PP2A pathway.
Title: Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy.
Tap42 functions in the same positive direction as Sit4, Pph21 and Pph22 in Ty1 transcriptional silencing, providing support to the idea that Tap42 may play a positive role in phosphatase activity in response to TORC1 signalling
Title: An essential role of Tap42-associated PP2A and 2A-like phosphatases in Ty1 transcriptional silencing of S. cerevisiae.
Here, we describe the crystal structure of the PP2Ac-interaction domain of Saccharomyces cerevisiae Tap42. The structure reveals an all alpha-helical protein with striking similarity to 14-3-3 and tetratricopeptide repeat (TPR) proteins.
Title: The structure of Tap42/alpha4 reveals a tetratricopeptide repeat-like fold and provides insights into PP2A regulation.
association of Phosphotyrosyl phosphatase activator with Tap42-phosphatase complexes is rapamycin sensitive
Title: The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes.
These findings suggest that the association of the Tap42-phosphatase complexes with TORC1 represents an important mechanism by which nutrient controls Tor signaling activity.
Title: Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase I	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Tap42p

NP_013741.1

Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits