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RCH1 Rch1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855050, updated on 3-Nov-2024

Summary

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Official Symbol
RCH1
Official Full Name
Rch1p
Primary source
SGD:S000004637
Locus tag
YMR034C
See related
AllianceGenome:SGD:S000004637; FungiDB:YMR034C; VEuPathDB:YMR034C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable monocarboxylic acid transmembrane transporter activity. Involved in negative regulation of cytosolic calcium ion concentration. Located in cellular bud neck and plasma membrane. Used to study amelogenesis imperfecta; osteochondrodysplasia; and osteoporosis. Orthologous to human SLC10A7 (solute carrier family 10 member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RCH1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (339418..340722, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Arp9p Neighboring gene endopeptidase catalytic subunit Neighboring gene putative tyrosine protein phosphatase MIH1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Calmodulin kinase 2 genetically interacts with Rch1p to negatively regulate calcium import into Saccharomyces cerevisiae after extracellular calcium pulse. Coleman CE, et al. Arch Microbiol, 2022 Jul 24. PMID 35871646
  2. Genetic analysis of azole resistance by transposon mutagenesis in Saccharomyces cerevisiae. Kontoyiannis DP. Antimicrob Agents Chemother, 1999 Nov. PMID 10543755, Free PMC Article
  3. The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast. Zhao Y, et al. Eur J Cell Biol, 2016 Mar-May. PMID 26832117
  4. Molecular and phylogenetic characterization of a novel putative membrane transporter (SLC10A7), conserved in vertebrates and bacteria. Godoy JR, et al. Eur J Cell Biol, 2007 Aug. PMID 17628207
  5. Functional profiling of the Saccharomyces cerevisiae genome. Giaever G, et al. Nature, 2002 Jul 25. PMID 12140549

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Saccharomyces cerevisiae Rch1 distribute as multiple foci in the plasma membrane prior to cell division, move toward and concentrate at the bud neck as the bud grows in size, and disperse again along the plasma membrane immediately prior to cytokinesis.
    Title: The plasma membrane protein Rch1 is a negative regulator of cytosolic calcium homeostasis and positively regulated by the calcium/calcineurin signaling pathway in budding yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables monocarboxylic acid transmembrane transporter activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monocarboxylic acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Rch1p
NP_013748.1
  • Negative regulator of cytosolic calcium homeostasis; localizes to the plasma membrane, concentrating at the bud neck during cell division; regulated by Crz1p through a CDRE promoter element; non-essential gene; putative transporter with sequence similarity to human SLC10A7; functional homolog of C. albicans RCH1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    339418..340722 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182531.1 → NP_013748.1  TPA: Rch1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013748.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZK9, Q05131
    UniProtKB/TrEMBL
    B3LLT3, B5VPG3, C7GL85, C8ZEP1, N1P5D3
    Conserved Domains (1) summary
    pfam13593
    Location:23 → 385
    SBF_like; SBF-like CPA transporter family (DUF4137)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05131.1

Gene LinkOut

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