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IOC4 Ioc4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855061, updated on 18-Sep-2024

Summary

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Official Symbol
IOC4
Official Full Name
Ioc4p
Primary source
SGD:S000004647
Locus tag
YMR044W
See related
AllianceGenome:SGD:S000004647; FungiDB:YMR044W; VEuPathDB:YMR044W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ATP hydrolysis activity and DNA binding activity. Involved in chromatin remodeling and sister chromatid cohesion. Part of Isw1b complex. Orthologous to several human genes including HDGFL1 (HDGF like 1); HDGFL2 (HDGF like 2); and HDGFL3 (HDGF like 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See IOC4 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (355384..356811)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Arg80p Neighboring gene transcription factor MCM1 Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-His

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin. Maltby VE, et al. Mol Cell Biol, 2012 Sep. PMID 22751925, Free PMC Article
  2. Isw1 acts independently of the Isw1a and Isw1b complexes in regulating transcriptional silencing at the ribosomal DNA locus in Saccharomyces cerevisiae. Mueller JE, et al. J Mol Biol, 2007 Aug 3. PMID 17561109, Free PMC Article
  3. Dependency of ISW1a chromatin remodeling on extranucleosomal DNA. Gangaraju VK, et al. Mol Cell Biol, 2007 Apr. PMID 17283061, Free PMC Article
  4. Analysis of nucleosome repositioning by yeast ISWI and Chd1 chromatin remodeling complexes. Stockdale C, et al. J Biol Chem, 2006 Jun 16. PMID 16606615, Free PMC Article
  5. Yeast Isw1p forms two separable complexes in vivo. Vary JC Jr, et al. Mol Cell Biol, 2003 Jan. PMID 12482963, Free PMC Article

See all (48) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Isw1b complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ioc4p
NP_013758.1
  • Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    355384..356811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182541.1 → NP_013758.1  TPA: Ioc4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013758.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZL9, Q04213
    UniProtKB/TrEMBL
    C7GL75, N1NYN4
    Conserved Domains (1) summary
    cd05840
    Location:6 → 161
    SPBC215_ISWI_like; The PWWP domain is a component of the S. pombe hypothetical protein SPBC215, as well as ISWI complex protein 4. The ISWI (imitation switch) proteins are ATPases responsible for chromatin remodeling in eukaryotes, and SPBC215 is proposed to also bind ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04213.1

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