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EUC1 Euc1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855138, updated on 18-Sep-2024

Summary

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Official Symbol
EUC1
Official Full Name
Euc1p
Primary source
SGD:S000004717
Locus tag
YMR111C
See related
AllianceGenome:SGD:S000004717; FungiDB:YMR111C; VEuPathDB:YMR111C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables sequence-specific DNA binding activity. Involved in protein-containing complex localization. Located in chromatin. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See EUC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (492404..493792, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene myosin 5 Neighboring gene hexadecenal dehydrogenase Neighboring gene Med11p Neighboring gene dihydrofolate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Global analyses of sumoylated proteins in Saccharomyces cerevisiae. Induction of protein sumoylation by cellular stresses. Zhou W, et al. J Biol Chem, 2004 Jul 30. PMID 15166219, Free PMC Article
  2. A proteomic strategy for gaining insights into protein sumoylation in yeast. Denison C, et al. Mol Cell Proteomics, 2005 Mar. PMID 15542864
  3. Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance. Höpfler M, et al. EMBO J, 2019 Jun 3. PMID 31015336, Free PMC Article
  4. Global analysis of protein sumoylation in Saccharomyces cerevisiae. Wohlschlegel JA, et al. J Biol Chem, 2004 Oct 29. PMID 15326169
  5. Distinct SUMO ligases cooperate with Esc2 and Slx5 to suppress duplication-mediated genome rearrangements. Albuquerque CP, et al. PLoS Genet, 2013. PMID 23935535, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein-containing complex localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
Euc1p
NP_013829.1
  • Sequence-specific DNA binding protein; binds to a sequence motif associated with distinct genomic hotspots of non-H2B protein ubiquitylation (ub-hotspots); interacts with Slx5p to recruit the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex to ub-hotspots; deletion prevents ub-hotspot formation and exacerbates heat sensitivity of cells deficient in Rpd3L histone deacetylase complex members; forms nuclear foci upon DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    492404..493792 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182611.1 → NP_013829.1  TPA: Euc1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013829.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT4, Q04461
    UniProtKB/TrEMBL
    A6ZMG8, B3LM02, C7GW98, C8ZEW4, G2WKG1, N1P0B9
    Conserved Domains (1) summary
    pfam12550
    Location:296 → 385
    GCR1_C; Transcriptional activator of glycolytic enzymes
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04461.1

Gene LinkOut

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