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ASC1 ribosomal 40S subunit protein ASC1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855143, updated on 28-Oct-2024

Summary

Official Symbol
ASC1
Official Full Name
ribosomal 40S subunit protein ASC1
Primary source
SGD:S000004722
Locus tag
YMR116C
See related
AllianceGenome:SGD:S000004722; FungiDB:YMR116C; VEuPathDB:YMR116C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ASU9; CPC2; NAD1
Summary
Enables G-protein alpha-subunit binding activity; GDP-dissociation inhibitor activity; and ribosome binding activity. Involved in several processes, including negative regulation of glucose mediated signaling pathway; nonfunctional rRNA decay; and post-transcriptional regulation of gene expression. Acts upstream of or within maintenance of translational fidelity. Located in cytoplasm. Part of cytosolic small ribosomal subunit. Orthologous to human RACK1 (receptor for activated C kinase 1). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

See ASC1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (499456..500688, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative peptide hydrolase Neighboring gene Mgr3p Neighboring gene ncRNA Neighboring gene kinetochore-associated Ndc80 complex subunit SPC24 Neighboring gene protein SHH3

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ribosome binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of cytosolic small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ribosomal 40S subunit protein ASC1
NP_013834.1
  • G-protein beta subunit and guanine dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; required to prevent frameshifting at ribosomes stalled at repeated CGA codons; regulates P-body formation induced by replication stress; represses Gcn4p in the absence of amino acid starvation; controls phosphorylation of multiple proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    499456..500688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182616.1NP_013834.1  TPA: ribosomal 40S subunit protein ASC1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013834.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT9, P38011, Q6LAA5
    UniProtKB/TrEMBL
    A6ZMH3, B3LM07, C7GW94, C8ZEW9, G2WKG6, N1NYE0