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PKR1 Pkr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855153, updated on 2-Nov-2024

Summary

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Official Symbol
PKR1
Official Full Name
Pkr1p
Primary source
SGD:S000004730
Locus tag
YMR123W
See related
AllianceGenome:SGD:S000004730; FungiDB:YMR123W; VEuPathDB:YMR123W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in vacuolar proton-transporting V-type ATPase complex assembly. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PKR1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (513593..513961)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ncw1p Neighboring gene Epo1p Neighboring gene Sto1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PKR1 encodes an assembly factor for the yeast V-type ATPase. Davis-Kaplan SR, et al. J Biol Chem, 2006 Oct 20. PMID 16926153
  2. Hph1 and Hph2 are novel components of the Sec63/Sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Piña FJ, et al. Eukaryot Cell, 2011 Jan. PMID 21097665, Free PMC Article
  3. Protein interaction networks by proteome peptide scanning. Landgraf C, et al. PLoS Biol, 2004 Jan. PMID 14737190, Free PMC Article
  4. Genome-scale genetic screen of lead ion-sensitive gene deletion mutations in Saccharomyces cerevisiae. Du J, et al. Gene, 2015 Jun 1. PMID 25773006
  5. Cdc1 removes the ethanolamine phosphate of the first mannose of GPI anchors and thereby facilitates the integration of GPI proteins into the yeast cell wall. Vazquez HM, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165136, Free PMC Article

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in vacuolar proton-transporting V-type ATPase complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar proton-transporting V-type ATPase complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuolar proton-transporting V-type ATPase complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pkr1p
NP_013842.1
  • V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    513593..513961
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182624.1 → NP_013842.1  TPA: Pkr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013842.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZU6, Q03880
    UniProtKB/TrEMBL
    A6ZMI3, C7GU95, C8ZEX8, N1NXD1
    Conserved Domains (1) summary
    pfam08636
    Location:4 → 73
    Pkr1; ER protein Pkr1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03880.1

Gene LinkOut

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