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GID8 glucose-induced degradation complex subunit GID8 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855166, updated on 18-Sep-2024

Summary

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Official Symbol
GID8
Official Full Name
glucose-induced degradation complex subunit GID8
Primary source
SGD:S000004742
Locus tag
YMR135C
See related
AllianceGenome:SGD:S000004742; FungiDB:YMR135C; VEuPathDB:YMR135C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
DCR1
Summary
Involved in negative regulation of gluconeogenesis; proteasome-mediated ubiquitin-dependent protein catabolic process; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleus. Part of GID complex. Orthologous to human GID8 (GID complex subunit 8 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See GID8 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (538689..540056, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rec114p Neighboring gene Erg29p Neighboring gene Gat2p Neighboring gene DNA cross-link repair protein PSO2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence. Childers DS, et al. PLoS Pathog, 2016 Apr. PMID 27073846, Free PMC Article
  2. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Pathak R, et al. Eukaryot Cell, 2004 Dec. PMID 15590836, Free PMC Article
  3. Regulation of the Gid ubiquitin ligase recognition subunit Gid4. Menssen R, et al. FEBS Lett, 2018 Oct. PMID 30136317
  4. Exploring the topology of the Gid complex, the E3 ubiquitin ligase involved in catabolite-induced degradation of gluconeogenic enzymes. Menssen R, et al. J Biol Chem, 2012 Jul 20. PMID 22645139, Free PMC Article
  5. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya LM, et al. Curr Genet, 2006 Jun. PMID 16552603

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hym1p requires Dcr2p(a phosphatase)and Gid8p (involved in protein degradation) to promote the transition from the G1 to S phase of the cell cycle
    Title: Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
  2. Gid8p (Dcr1p) and Dcr2p have roles in a common pathway to promote START completion in Saccharomyces cerevisiae
    Title: Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in negative regulation of gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in traversing start control point of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of GID complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
glucose-induced degradation complex subunit GID8
NP_013854.1
  • Subunit of GID Complex, binds strongly to central component Vid30p; GID Complex is involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; recruits Rmd5p, Fyv10 and Vid28p to GID Complex; contains LisH, CTLH, and CRA domains that mediate binding to Vid30p (LisH) and Rmd5p and Vid28p (CTLH and CRA); dosage-dependent regulator of START

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    538689..540056 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182636.1 → NP_013854.1  TPA: glucose-induced degradation complex subunit GID8 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013854.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZV8, P40208
    UniProtKB/TrEMBL
    B3LM22, C8ZEZ0
    Conserved Domains (1) summary
    pfam10607
    Location:130 → 296
    CLTH; CTLH/CRA C-terminal to LisH motif domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40208.1

Gene LinkOut

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