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INP2 Inp2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855198, updated on 28-Oct-2024

Summary

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Official Symbol
INP2
Official Full Name
Inp2p
Primary source
SGD:S000004773
Locus tag
YMR163C
See related
AllianceGenome:SGD:S000004773; FungiDB:YMR163C; VEuPathDB:YMR163C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-membrane adaptor activity. Involved in peroxisome inheritance. Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See INP2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (584271..586388, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene type I HSP40 co-chaperone HLJ1 Neighboring gene aminophospholipid-translocating P4-type ATPase DNF3 Neighboring gene tRNA-Val Neighboring gene Mss11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myosin-driven peroxisome partitioning in S. cerevisiae. Fagarasanu A, et al. J Cell Biol, 2009 Aug 24. PMID 19687257, Free PMC Article
  2. The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae. Fagarasanu A, et al. Dev Cell, 2006 May. PMID 16678774
  3. Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p. Otzen M, et al. Traffic, 2012 Jul. PMID 22486971
  4. Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. Choudhry SK, et al. J Cell Sci, 2018 Feb 7. PMID 29361529
  5. Structural mechanism for versatile cargo recognition by the yeast class V myosin Myo2. Tang K, et al. J Biol Chem, 2019 Apr 12. PMID 30804213, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inp2p together with Pex19p is required for proper association of peroxisomes to Myo2p.
    Title: Pex19p contributes to peroxisome inheritance in the association of peroxisomes to Myo2p.
  2. Inp2p is the first peroxisomal protein implicated in the vectorial movement of peroxisomes.Inp2p interacts directly with the globular tail of Myo2p.
    Title: The peroxisomal membrane protein Inp2p is the peroxisome-specific receptor for the myosin V motor Myo2p of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-membrane adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein-membrane adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome inheritance IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome inheritance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peroxisome inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peroxisome inheritance IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Inp2p
NP_013886.1
  • Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    584271..586388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182667.1 → NP_013886.1  TPA: Inp2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013886.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZY5, Q03824
    UniProtKB/TrEMBL
    C8ZF23, G2WKL6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03824.1

Gene LinkOut

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