PAH1 phosphatidate phosphatase PAH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PAH1
Official Full Name: phosphatidate phosphatase PAH1
Primary source: SGD:S000004775
Locus tag: YMR165C
See related: AllianceGenome:SGD:S000004775; FungiDB:YMR165C; VEuPathDB:YMR165C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SMP2
Summary: Enables phosphatidate phosphatase activity and transcription cis-regulatory region binding activity. Involved in several processes, including lipid droplet organization; triglyceride biosynthetic process; and vacuole fusion, non-autophagic. Located in cytosol; lipid droplet; and vacuole. Is active in nuclear membrane. Used to study lipid metabolism disorder and myoglobinuria. Human ortholog(s) of this gene implicated in chronic recurrent multifocal osteomyelitis. Orthologous to human LPIN1 (lipin 1); LPIN2 (lipin 2); and LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See PAH1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (590040..592628, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis.
Title: Phosphatidate phosphatase Pah1 contains a novel RP domain that regulates its phosphorylation and function in yeast lipid synthesis.
Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
Title: Glycogen synthase kinase homolog Rim11 regulates lipid synthesis through the phosphorylation of Pah1 phosphatidate phosphatase in yeast.
Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
Title: Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.
Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast.
Title: Mutant phosphatidate phosphatase Pah1-W637A exhibits altered phosphorylation, membrane association, and enzyme function in yeast.
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
Title: Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities.
Title: NLIP and HAD-like Domains of Pah1 and Lipin 1 Phosphatidate Phosphatases Are Essential for Their Catalytic Activities.
Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer.
Title: Yeast phosphatidic acid phosphatase Pah1 hops and scoots along the membrane phospholipid bilayer.
The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
Title: The Spo7 sequence LLI is required for Nem1-Spo7/Pah1 phosphatase cascade function in yeast lipid metabolism.
Results indicate that phosphatidate phosphatase PAH1 (Pah1) is phosphorylated by the serine/threonine protein kinase YCK1 (YCK1)-encoded casein kinase I (CKI), regulating Pah1 catalytic activity and phosphorylation.
Title: Yck1 casein kinase I regulates the activity and phosphorylation of Pah1 phosphatidate phosphatase from Saccharomyces cerevisiae.
the TORC1-Nem1/Spo7-Pah1 axis is a master regulator of not only macroautophagy but also microautophagy in budding yeast
Title: The TORC1-Nem1/Spo7-Pah1/lipin axis regulates microautophagy induction in budding yeast.

Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidate phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidate phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidate phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmid maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuole fusion, non-autophagic	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in vacuole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosphatidate phosphatase PAH1

NP_013888.1

EC 3.1.3.4

Mg2+-dependent phosphatidate (PA) phosphatase; dephosphorylates PA to yield diacylglycerol; regulates phospholipid synthesis, nuclear/ER membrane growth, lipid droplet formation, triacylglycerol synthesis, vacuolar homeostasis and cell wall integrity; phosphorylated by Pho85p/Pho80p, Cdc28p/Cyclin B, PKA, PKC, and CKII, regulating activity, localization, and proteosomal degradation; homolog of mammalian lipins 1 and 2; human homologs LPIN1, LPIN2, LPIN3 complement the null

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

590040..592628 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182669.1 → NP_013888.1 TPA: phosphatidate phosphatase PAH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013888.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZY7, P32567

UniProtKB/TrEMBL

G2WKL8

Conserved Domains (1) summary

COG5083
Location:1 → 609

SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]