ALD3 aldehyde dehydrogenase (NAD(+)) ALD3 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ALD3
Official Full Name: aldehyde dehydrogenase (NAD(+)) ALD3
Primary source: SGD:S000004779
Locus tag: YMR169C
See related: AllianceGenome:SGD:S000004779; FungiDB:YMR169C; VEuPathDB:YMR169C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables aldehyde dehydrogenase (NAD+) activity. Involved in beta-alanine biosynthetic process and polyamine catabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ALD3 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (599352..600872, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables aldehyde dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldehyde dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables aldehyde dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in beta-alanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pantothenate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in polyamine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in polyamine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: aldehyde dehydrogenase (NAD(+)) ALD3

NP_013892.1

EC 1.2.1.3

Cytoplasmic aldehyde dehydrogenase; involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

599352..600872 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182673.1 → NP_013892.1 TPA: aldehyde dehydrogenase (NAD(+)) ALD3 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013892.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZZ1, P54114

UniProtKB/TrEMBL

A6ZMM8, B3LM56, G2WKM2

Conserved Domains (1) summary

cl11961
Location:14 → 502

ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily