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SSO2 syntaxin [ Saccharomyces cerevisiae S288C ]

Gene ID: 855221, updated on 28-Oct-2024

Summary

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Official Symbol
SSO2
Official Full Name
syntaxin
Primary source
SGD:S000004795
Locus tag
YMR183C
See related
AllianceGenome:SGD:S000004795; FungiDB:YMR183C; VEuPathDB:YMR183C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables SNAP receptor activity and phosphatidic acid binding activity. Involved in ascospore-type prospore assembly. Located in plasma membrane and prospore membrane. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Hirschsprung's disease; congenital diarrhea; familial hemophagocytic lymphohistiocytosis 4; and generalized epilepsy with febrile seizures plus 9. Orthologous to several human genes including STX1A (syntaxin 1A). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See SSO2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (626921..627808, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Min3p Neighboring gene ncRNA Neighboring gene Add37p Neighboring gene Rtp1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Membrane insertion and intracellular transport of yeast syntaxin Sso2p in mammalian cells. Jäntti J, et al. J Cell Sci, 1994 Dec. PMID 7706411
  2. Development of a Saccharomyces cerevisiae strain with enhanced resistance to phenolic fermentation inhibitors in lignocellulose hydrolysates by heterologous expression of laccase. Larsson S, et al. Appl Environ Microbiol, 2001 Mar. PMID 11229906, Free PMC Article
  3. SNAREs and the secretory pathway-lessons from yeast. Pelham HR. Exp Cell Res, 1999 Feb 25. PMID 10047442
  4. Enhancement of protein secretion in Saccharomyces cerevisiae by overproduction of Sso protein, a late-acting component of the secretory machinery. Ruohonen L, et al. Yeast, 1997 Mar 30. PMID 9133737
  5. Mapping of sporulation-specific functions in the yeast syntaxin gene SSO1. Oyen M, et al. Curr Genet, 2004 Feb. PMID 14652692

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggested that Sso2p plays a role in maintaining the lipid composition of the plasma membrane and the increase in unsaturated fatty acids amplified the production of ROS in the acute phase of aluminium stress. ROS derived from aluminium stress inhibited growth and resulted in the susceptibility of the Deltasso2 strain.
    Title: Decreased aluminium tolerance in the growth of Saccharomyces cerevisiae with SSO2 gene disruption.
  2. Data indicate the binding kinetic properties of three SNAREs: Sec22p, Ykt6p and Sso2p.
    Title: Analysis of interactions between SNARE proteins using imaging ellipsometer coupled with microfluidic array.
  3. The Sso1, but not SSo2, is essential for prospore membrane formation.
    Title: Phosphatidylinositol-4,5-bisphosphate and phospholipase D-generated phosphatidic acid specify SNARE-mediated vesicle fusion for prospore membrane formation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNAP receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables SNAP receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in ascospore-type prospore assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle docking IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell periphery HDA PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in prospore membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
syntaxin
NP_013908.1
  • Plasma membrane t-SNARE; involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p; SSO2 has a paralog, SSO1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    626921..627808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182689.1 → NP_013908.1  TPA: syntaxin [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W007, P39926
    UniProtKB/TrEMBL
    A6ZMP4, B3LM70, C7GTR7, C8ZF47, G2WKN8, N1NYJ6
    Conserved Domains (1) summary
    COG5074
    Location:1 → 280
    COG5074; t-SNARE complex subunit, syntaxin [Intracellular trafficking, secretion, and vesicular transport]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39926.2

Gene LinkOut

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