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INP1 Inp1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855244, updated on 28-Oct-2024

Summary

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Official Symbol
INP1
Official Full Name
Inp1p
Primary source
SGD:S000004817
Locus tag
YMR204C
See related
AllianceGenome:SGD:S000004817; FungiDB:YMR204C; VEuPathDB:YMR204C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein-macromolecule adaptor activity. Involved in peroxisome inheritance. Located in peroxisome. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See INP1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (670063..671325, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene C-8 sterol isomerase ERG2 Neighboring gene Tom40p Neighboring gene 6-phosphofructokinase subunit beta Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Δinp1 and Δpex11. Scheckhuber CQ. Folia Microbiol (Praha), 2020 Apr. PMID 31273644
  2. Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast. Krikken AM, et al. J Cell Biol, 2020 Oct 5. PMID 32805027, Free PMC Article
  3. An ER-peroxisome tether exerts peroxisome population control in yeast. Knoblach B, et al. EMBO J, 2013 Sep 11. PMID 23900285, Free PMC Article
  4. A dual function for Pex3p in peroxisome formation and inheritance. Munck JM, et al. J Cell Biol, 2009 Nov 16. PMID 19948495, Free PMC Article
  5. Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. Choudhry SK, et al. J Cell Sci, 2018 Feb 7. PMID 29361529

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
    Title: The Pex3-Inp1 complex tethers yeast peroxisomes to the plasma membrane.
  2. Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
    Title: Peroxisome retention involves Inp1-dependent peroxisome-plasma membrane contact sites in yeast.
  3. Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Deltainp1 and Deltapex11.
    Title: Characterization of survival and stress resistance in S. cerevisiae mutants affected in peroxisome inheritance and proliferation, Δinp1 and Δpex11.
  4. Inp1p acts as a molecular hinge between ER-bound Pex3p and peroxisomal Pex3p.
    Title: An ER-peroxisome tether exerts peroxisome population control in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in peroxisome inheritance IEA
Inferred from Electronic Annotation
more info
  
involved_in peroxisome inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of intraperoxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome HDA PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Inp1p
NP_013931.1
  • Peripheral membrane protein of peroxisomes; involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane; Inp1p and Pex3p tether peroxisomes to plasma membrane

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    670063..671325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182711.1 → NP_013931.1  TPA: Inp1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013931.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZMR6, D6W029, Q03694
    UniProtKB/TrEMBL
    B3LM92, B5VPX2, C8ZF69, G2WKR0, N1NYZ4
    Conserved Domains (1) summary
    pfam12634
    Location:79 → 260
    Inp1; Inheritance of peroxisomes protein 1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03694.1

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