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ORA1 oxidoreductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855266, updated on 28-Oct-2024

Summary

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Official Symbol
ORA1
Official Full Name
oxidoreductase
Primary source
SGD:S000004839
Locus tag
YMR226C
See related
AllianceGenome:SGD:S000004839; FungiDB:YMR226C; VEuPathDB:YMR226C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables carbonyl reductase (NADPH) activity; diacetyl reductase ((S)-acetoin forming) (NAD+) activity; and serine 3-dehydrogenase activity. Involved in acetoin metabolic process. Located in nucleus. Is active in cytoplasm. Orthologous to human DHRS11 (dehydrogenase/reductase 11). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ORA1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (721593..722396, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene MRX complex nuclease subunit Neighboring gene mitochondrial 54S ribosomal protein YmL44 Neighboring gene TATA-binding protein-associated factor TAF7 Neighboring gene RNA polymerase specificity factor

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Asymmetric synthesis of both antipodes of beta-hydroxy nitriles and beta-hydroxy carboxylic acids via enzymatic reduction or sequential reduction/hydrolysis. Ankati H, et al. J Org Chem, 2009 Feb 20. PMID 19161324
  2. Characterization of short-chain dehydrogenase/reductase homologues of Escherichia coli (YdfG) and Saccharomyces cerevisiae (YMR226C). Fujisawa H, et al. Biochim Biophys Acta, 2003 Jan 31. PMID 12535615
  3. Reaction and strain engineering for improved stereo-selective whole-cell reduction of a bicyclic diketone. Johanson T, et al. Appl Microbiol Biotechnol, 2008 Jan. PMID 17962934
  4. Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry. Ankati H, et al. J Org Chem, 2008 Aug 15. PMID 18630881
  5. 1-Acyldihydroxyacetone-phosphate reductase (Ayr1p) of the yeast Saccharomyces cerevisiae encoded by the open reading frame YIL124w is a major component of lipid particles. Athenstaedt K, et al. J Biol Chem, 2000 Jan 7. PMID 10617610

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diacetyl reductase ((S)-acetoin forming) (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
enables serine 3-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetoin metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oxidoreductase
NP_013953.1
  • NADP(+)-dependent serine dehydrogenase and carbonyl reductase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; catalyzes the reduction of (S)-alpha-acetolactate to 2,3-dimethylglycerate; short-chain dehydrogenase/reductase (SDR) family member; GFP fusion protein localizes to the cytoplasm and nucleus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    721593..722396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182733.1 → NP_013953.1  TPA: oxidoreductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013953.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W051, Q05016
    UniProtKB/TrEMBL
    A6ZMT8, B3LMB4, B5VPZ4, C7GRC5, C8ZF90, G2WKT3, N1P5V4
    Conserved Domains (1) summary
    cd05346
    Location:14 → 266
    SDR_c5; classical (c) SDR, subgroup 5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05016.1

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