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PEP5 tethering complex subunit PEP5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855271, updated on 18-Sep-2024

Summary

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Official Symbol
PEP5
Official Full Name
tethering complex subunit PEP5
Primary source
SGD:S000004844
Locus tag
YMR231W
See related
AllianceGenome:SGD:S000004844; FungiDB:YMR231W; VEuPathDB:YMR231W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
END1; VAM1; VPL9; VPS11; VPT11
Summary
Enables ubiquitin protein ligase activity. Contributes to phosphatidylinositol binding activity. Involved in several processes, including Golgi to endosome transport; cellular protein metabolic process; and vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane. Part of CORVET complex and HOPS complex. Used to study hypomyelinating leukodystrophy 12. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 12. Orthologous to human VPS11 (VPS11 core subunit of CORVET and HOPS complexes). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PEP5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (733545..736634)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S10B Neighboring gene uncharacterized protein Neighboring gene Fus2p Neighboring gene Tri1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of protein processing, intracellular trafficking and endocytosis in production of and immunity to yeast killer toxin. Douglas CM, et al. Eur J Epidemiol, 1988 Dec. PMID 3060366
  2. Characterization of the END1 gene required for vacuole biogenesis and gluconeogenic growth of budding yeast. Dulić V, et al. EMBO J, 1989 May. PMID 2670552, Free PMC Article
  3. Isolation and characterization of PEP5, a gene essential for vacuolar biogenesis in Saccharomyces cerevisiae. Woolford CA, et al. Genetics, 1990 Aug. PMID 2204580, Free PMC Article
  4. Hypomyelination and developmental delay associated with VPS11 mutation in Ashkenazi-Jewish patients. Edvardson S, et al. J Med Genet, 2015 Nov. PMID 26307567
  5. Nystatin effects on vacuolar function in Saccharomyces cerevisiae. Bhuiyan MS, et al. Biosci Biotechnol Biochem, 1999 Jun. PMID 10427694

See all (113) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to phosphatidylinositol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi to endosome transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histone catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in late endosome to vacuole transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in organelle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of SNARE complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vacuole fusion, non-autophagic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vacuole organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle docking involved in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle tethering IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CORVET complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of HOPS complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of HOPS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in bounding membrane of organelle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  
part_of vesicle tethering complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tethering complex subunit PEP5
NP_013958.1
  • Histone E3 ligase, component of CORVET membrane tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p; involved in ubiquitination and degradation of excess histones

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    733545..736634
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182738.1 → NP_013958.1  TPA: tethering complex subunit PEP5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W057, P12868
    UniProtKB/TrEMBL
    B3LMC0, B5VPZ9, N1NZ20
    Conserved Domains (3) summary
    cd00162
    Location:928 → 972
    RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
    pfam12451
    Location:976 → 1021
    VPS11_C; Vacuolar protein sorting protein 11 C terminal
    cl17238
    Location:928 → 975
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12868.2

Gene LinkOut

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