U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RCE1 CAAX prenyl protease [ Saccharomyces cerevisiae S288C ]

Gene ID: 855317, updated on 29-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
RCE1
Gene description
CAAX prenyl protease
Primary source
FungiDB:YMR274C
Locus tag
YMR274C
See related
SGD:S000004887; AllianceGenome:SGD:S000004887; VEuPathDB:YMR274C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables metalloendopeptidase activity. Involved in CAAX-box protein processing and peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion. Is integral component of endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RCE1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (814364..815311, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Zds1p Neighboring gene ubiquitin-ubiquitin ligase BUL1 Neighboring gene ubiquitin domain-containing protein DSK2

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Topology of the yeast Ras converting enzyme as inferred from cysteine accessibility studies. Hildebrandt ER, et al. Biochemistry, 2013 Sep 24. PMID 23972033, Free PMC Article
  2. Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: improved labeling and structural implications. Kyro K, et al. Bioorg Med Chem, 2011 Dec 15. PMID 22079863, Free PMC Article
  3. Small-molecule inhibitors of the Rce1p CaaX protease. Manandhar SP, et al. J Biomol Screen, 2007 Oct. PMID 17942791, Free PMC Article
  4. The multispanning membrane protein Ste24p catalyzes CAAX proteolysis and NH2-terminal processing of the yeast a-factor precursor. Tam A, et al. J Biol Chem, 2001 Dec 14. PMID 11581258
  5. Studies with recombinant Saccharomyces cerevisiae CaaX prenyl protease Rce1p. Dolence JM, et al. Biochemistry, 2000 Apr 11. PMID 10747800

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the ras converting enzyme requires its glutamate and histidine residues
    Title: Mutational analysis of the ras converting enzyme reveals a requirement for glutamate and histidine residues.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metalloendopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAAX-box protein maturation IEA
Inferred from Electronic Annotation
more info
  
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAAX-box protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in CAAX-box protein processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in CAAX-box protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptide mating pheromone maturation involved in positive regulation of conjugation with cellular fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in response to pheromone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
CAAX prenyl protease
NP_014001.1
  • Type II CAAX prenyl protease; involved in the proteolysis and maturation of Ras and the a-factor mating pheromone

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    814364..815311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182781.1 → NP_014001.1  TPA: CAAX prenyl protease [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014001.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0A1, Q03530
    UniProtKB/TrEMBL
    A0A6L1A4Z6, B3LMG2, B5VQ40, C7GTM5, C8ZFE1
    Conserved Domains (1) summary
    pfam02517
    Location:143 → 254
    Abi; CAAX protease self-immunity
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03530.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous