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JNM1 Jnm1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855339, updated on 29-Jun-2024

Summary

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Gene symbol
JNM1
Gene description
Jnm1p
Primary source
FungiDB:YMR294W
Locus tag
YMR294W
See related
SGD:S000004908; AllianceGenome:SGD:S000004908; VEuPathDB:YMR294W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
INS1; PAC3
Summary
A structural constituent of cytoskeleton. Involved in establishment of mitotic spindle orientation and nuclear migration. Part of dynactin complex. Orthologous to human DCTN2 (dynactin subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See JNM1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (856966..858087)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Got1p Neighboring gene glutamyl-tRNA(Gln) amidotransferase subunit HER2 Neighboring gene Gsr1p Neighboring gene serine C-palmitoyltransferase LCB1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The JNM1 gene in the yeast Saccharomyces cerevisiae is required for nuclear migration and spindle orientation during the mitotic cell cycle. McMillan JN, et al. J Cell Biol, 1994 Apr. PMID 8138567, Free PMC Article
  2. Alanine scanning of Arp1 delineates a putative binding site for Jnm1/dynamitin and Nip100/p150Glued. Clark SW, et al. Mol Biol Cell, 2005 Sep. PMID 15975903, Free PMC Article
  3. The Saccharomyces cerevisiae SRK1 gene, a suppressor of bcy1 and ins1, may be involved in protein phosphatase function. Wilson RB, et al. Mol Cell Biol, 1991 Jun. PMID 1645449, Free PMC Article
  4. A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Muhua L, et al. Nature, 1998 Jun 4. PMID 9624007, Free PMC Article
  5. A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Costigan C, et al. Mol Cell Biol, 1992 Mar. PMID 1545797, Free PMC Article

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based process IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of dynactin complex IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Jnm1p
NP_014022.1
  • Component of the yeast dynactin complex; consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    856966..858087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182802.1 → NP_014022.1  TPA: Jnm1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0C1, P36224
    UniProtKB/TrEMBL
    A0A8H4BZ17, B3LMI2, G2WL03
    Conserved Domains (1) summary
    pfam04912
    Location:175 → 363
    Dynamitin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36224.2

Gene LinkOut

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