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DYN3 dynein light intermediate chain [ Saccharomyces cerevisiae S288C ]

Gene ID: 855345, updated on 18-Sep-2024

Summary

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Official Symbol
DYN3
Official Full Name
dynein light intermediate chain
Primary source
SGD:S000004914
Locus tag
YMR299C
See related
AllianceGenome:SGD:S000004914; FungiDB:YMR299C; VEuPathDB:YMR299C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to cytoskeletal motor activity. Involved in nuclear migration along microtubule. Located in cytoplasmic microtubule. Part of cytoplasmic dynein complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DYN3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (864412..865350, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene carboxypeptidase C PRC1 Neighboring gene sphingosine N-acyltransferase subunit LIP1 Neighboring gene amidophosphoribosyltransferase Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cytoplasmic dynein moves through uncoordinated stepping of the AAA+ ring domains. DeWitt MA, et al. Science, 2012 Jan 13. PMID 22157083, Free PMC Article
  2. The offloading model for dynein function: differential function of motor subunits. Lee WL, et al. J Cell Biol, 2005 Jan 17. PMID 15642746, Free PMC Article
  3. Dynein achieves processive motion using both stochastic and coordinated stepping. Qiu W, et al. Nat Struct Mol Biol, 2012 Jan 8. PMID 22231401, Free PMC Article
  4. Regulated offloading of cytoplasmic dynein from microtubule plus ends to the cortex. Markus SM, et al. Dev Cell, 2011 May 17. PMID 21571221, Free PMC Article
  5. Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity. Marzo MG, et al. Nat Cell Biol, 2020 May. PMID 32341548, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LIC/Dyn3 has a role in dynein function which providing new insight into the offloading model.
    Title: The offloading model for dynein function: differential function of motor subunits.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to cytoskeletal motor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in nuclear migration along microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytoplasmic dynein complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein light intermediate chain
NP_014028.2
  • Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    864412..865350 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182808.2 → NP_014028.2  TPA: dynein light intermediate chain [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014028.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0C6, Q03592, Q04949
    UniProtKB/TrEMBL
    A6ZN15, B3LMI7, B5VQ65, C7GTK0, C8ZFG8, G2WL08
    Conserved Domains (1) summary
    pfam05783
    Location:163 → 301
    DLIC; Dynein light intermediate chain (DLIC)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04949.2

Gene LinkOut

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