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ADE4 amidophosphoribosyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855346, updated on 2-Nov-2024

Summary

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Official Symbol
ADE4
Official Full Name
amidophosphoribosyltransferase
Primary source
SGD:S000004915
Locus tag
YMR300C
See related
AllianceGenome:SGD:S000004915; FungiDB:YMR300C; VEuPathDB:YMR300C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables amidophosphoribosyltransferase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytoplasm. Orthologous to human PPAT (phosphoribosyl pyrophosphate amidotransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ADE4 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (865559..867091, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene sphingosine N-acyltransferase subunit LIP1 Neighboring gene dynein light intermediate chain Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1 Neighboring gene Yme2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional activation of yeast nucleotide biosynthetic gene ADE4 by GCN4. Mösch HU, et al. J Biol Chem, 1991 Oct 25. PMID 1939099
  2. Isolation of a human cDNA encoding amidophosphoribosyltransferase and functional complementation of a CHO Ade-A mutant deficient in this activity. Barton JW, et al. Somat Cell Mol Genet, 1991 May. PMID 2047942
  3. [Properties of 5-phosphoryl-1-pyrophosphate amidotransferase from the yeast Saccharomyces cerevisiae wild type and mutant with altered purine biosynthesis regulation]. Smolina VS, et al. Biokhimiia, 1982 Jan. PMID 7039693
  4. Studies on mutants affecting amidophosphoribosyltransferase activity in Saccharomyces cerevisiae. Nieto DJ, et al. Can J Microbiol, 1983 Jun. PMID 6349762
  5. Glutamine nucleotide sequence of Saccharomyces cerevisiae ADE4 encoding phosphoribosylpyrophosphate amidotransferase. Mäntsälä P, et al. J Biol Chem, 1984 Jul 10. PMID 6376509

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amidophosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables amidophosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amidophosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables amidophosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' IMP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
amidophosphoribosyltransferase
NP_014029.1
  • Phosphoribosylpyrophosphate amidotransferase (PRPPAT); catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway; also known as amidophosphoribosyltransferase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    865559..867091 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182809.1 → NP_014029.1  TPA: amidophosphoribosyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014029.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0C7, P04046
    UniProtKB/TrEMBL
    A6ZN16, B3LMI8, B5VQ66, C7GTJ9, G2WL09, N1P632
    Conserved Domains (1) summary
    PRK09246
    Location:1 → 502
    PRK09246; amidophosphoribosyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04046.2

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