ATM1 ATP-binding cassette Fe/S cluster precursor transporter ATM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ATM1
Official Full Name: ATP-binding cassette Fe/S cluster precursor transporter ATM1
Primary source: SGD:S000004916
Locus tag: YMR301C
See related: AllianceGenome:SGD:S000004916; FungiDB:YMR301C; VEuPathDB:YMR301C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATPase-coupled transmembrane transporter activity. Involved in iron-sulfur cluster assembly. Acts upstream of or within iron-sulfur cluster transmembrane transport. Located in mitochondrial inner membrane. Used to study X-linked sideroblastic anemia with ataxia. Human ortholog(s) of this gene implicated in X-linked sideroblastic anemia with ataxia. Orthologous to human ABCB7 (ATP binding cassette subfamily B member 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ATM1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (867555..869627, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

growth phenotype of atm3-1 was strongly enhanced by depletion of the mitochondrion-localized, GSH-dependent persulfide oxygenase ETHE1, suggesting that the physiological substrate of ATM3 contains persulfide in addition to glutathione
Title: A conserved mitochondrial ATP-binding cassette transporter exports glutathione polysulfide for cytosolic metal cofactor assembly.
this study reports the crystal structures of free and glutathione-bound Atm1 in inward-facing, open conformations at 3.06- and 3.38-angstrom resolution, respectively.
Title: Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1.
Compared to wild-type mitochondria, iron-sulfur cluster and heme levels in Atm1p-depleted mitochondria from aerobic cells are diminished. Atm1p depletion causes a buildup of nonheme ferrous ions in mitochondria and an increase in oxidative damage.
Title: Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae.
Structural analysis of Atm1p by CD spectroscopy suggested a similarity of secondary structure to that found for other members of this ABC protein family
Title: Characterization of Saccharomyces cerevisiae Atm1p: functional studies of an ABC7 type transporter.
the physiological substrate of Atm1p may contain multiple sulfhydryl groups in a peptidic environment
Title: Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase-coupled transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within iron-sulfur cluster transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP-binding cassette Fe/S cluster precursor transporter ATM1

NP_014030.1

Mitochondrial inner membrane ATP-binding cassette (ABC) transporter; exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol; human homolog ABCB7 can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

867555..869627 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182810.1 → NP_014030.1 TPA: ATP-binding cassette Fe/S cluster precursor transporter ATM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014030.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0C8, P40416

UniProtKB/TrEMBL

A6ZN17, C7GTJ8, G2WL10, N1P0R9

Conserved Domains (1) summary

COG5265
Location:174 → 673

ATM1; ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]