ADH2 alcohol dehydrogenase ADH2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADH2
Official Full Name: alcohol dehydrogenase ADH2
Primary source: SGD:S000004918
Locus tag: YMR303C
See related: AllianceGenome:SGD:S000004918; FungiDB:YMR303C; VEuPathDB:YMR303C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ADR2
Summary: Enables alcohol dehydrogenase (NAD+) activity. Involved in NADH oxidation; amino acid catabolic process to alcohol via Ehrlich pathway; and ethanol metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ADH2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (873291..874337, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADH2 proved to have ethanol dehydrogenase activity.
Title: [Cloning, expression and evaluation of Saccharomyces cerevisiae ADH2].
ADH2 expression in the med14 mutant is stimulated by Adr1.
Title: Snf1-independent, glucose-resistant transcription of Adr1-dependent genes in a mediator mutant of Saccharomyces cerevisiae.
ADH2 expression was dependent on these factors with wild-type Adr1
Title: Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression.
the absence of the Isw1 and Chd1 ATP-dependent chromatin remodelling activities delays the maximal expression of ADH2 without impairing the chromatin remodelling that occurs upon activation
Title: The ISWI and CHD1 chromatin remodelling activities influence ADH2 expression and chromatin organization.
analysis of Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae
Title: Snf1-dependent and Snf1-independent pathways of constitutive ADH2 expression in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables butanol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in NADH oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in amino acid catabolic process to alcohol via Ehrlich pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ethanol metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alcohol dehydrogenase ADH2

NP_014032.1

EC 1.1.1.1

Glucose-repressible alcohol dehydrogenase II; catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

873291..874337 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182812.1 → NP_014032.1 TPA: alcohol dehydrogenase ADH2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014032.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0D0, P00331

UniProtKB/TrEMBL

A0A0B4VJL3, G2WL12

Conserved Domains (1) summary

cd08297
Location:7 → 345

CAD3; Cinnamyl alcohol dehydrogenases (CAD)