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PSE1 Pse1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855356, updated on 2-Nov-2024

Summary

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Official Symbol
PSE1
Official Full Name
Pse1p
Primary source
SGD:S000004925
Locus tag
YMR308C
See related
AllianceGenome:SGD:S000004925; FungiDB:YMR308C; VEuPathDB:YMR308C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
KAP121
Summary
Enables nuclear import signal receptor activity and nuclear localization sequence binding activity. Involved in nucleocytoplasmic transport; regulation of mitotic nuclear division; and regulation of protein desumoylation. Located in cytoplasm and nucleus. Used to study cancer. Orthologous to human RANBP6 (RAN binding protein 6) and IPO5 (importin 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PSE1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (888952..892221, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene putative 1,3-beta-D-glucan synthase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene translation initiation factor eIF3 core subunit c Neighboring gene putative methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Screening and identification of a gene, PSE-1, that affects protein secretion in Saccharomyces cerevisiae. Chow TY, et al. J Cell Sci, 1992 Mar. PMID 1522152
  2. Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p. Kobayashi J, et al. Biochem Biophys Res Commun, 2015 Jul 31. PMID 26022122
  3. Functional and physical interactions between autonomously replicating sequence-binding factor 1 and the nuclear transport machinery. Loch CM, et al. Traffic, 2004 Dec. PMID 15522095
  4. Pse1p mediates the nuclear import of the iron-responsive transcription factor Aft1p in Saccharomyces cerevisiae. Ueta R, et al. J Biol Chem, 2003 Dec 12. PMID 14523005
  5. The core protein of hepatitis C virus is imported into the nucleus by transport receptor Kap123p but inhibits Kap121p-dependent nuclear import of yeast AP1-like transcription factor in yeast cells. Isoyama T, et al. J Biol Chem, 2002 Oct 18. PMID 12167639

See all (136) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The RanGTP-resistant interactions of Kap121 with the Dam1 complex would allow Kap121 to escort the complex to its destination on kinetochore-associated microtubule ends.
    Title: The Nuclear Transport Factor Kap121 Is Required for Stability of the Dam1 Complex and Mitotic Kinetochore Bi-orientation.
  2. The crystal structure of Kap121p-Cdc14p complex is determined.
    Title: Crystal structure of the karyopherin Kap121p bound to the extreme C-terminus of the protein phosphatase Cdc14p.
  3. Comparison of the nuclear localization signal and RanGTP complexes reveals that RanGTP binding not only occludes the cargo-binding site but also forces Kap121p into a conformation that is incompatible with nuclear localization signal recognition.
    Title: Structural basis for cell-cycle-dependent nuclear import mediated by the karyopherin Kap121p.
  4. The PSE1 specifically binds to histones H2A and H2B.
    Title: The histones H2A/H2B and H3/H4 are imported into the yeast nucleus by different mechanisms.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables nuclear import signal receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear import signal receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables nuclear import signal receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear localization sequence binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nuclear localization sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA export from nucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein import into nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein desumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein desumoylation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pse1p
NP_014039.1
  • Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p; required for stability of the Dam1p-Duo1p complex

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    888952..892221 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182819.1 → NP_014039.1  TPA: Pse1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014039.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0D5, P32337
    UniProtKB/TrEMBL
    B3LMJ6, C7GPV5, G2WL17, N1NYW3
    Conserved Domains (6) summary
    sd00044
    Location:106 → 128
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:396 → 435
    HEAT_EZ; HEAT-like repeat
    pfam13646
    Location:403 → 475
    HEAT_2; HEAT repeats
    pfam18808
    Location:274 → 365
    Importin_rep_4; Importin repeat
    pfam18816
    Location:1001 → 1054
    Importin_rep_5; Importin repeat
    pfam18829
    Location:766 → 868
    Importin_rep_6; Importin repeat 6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32337.2

Gene LinkOut

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