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ERR3 phosphopyruvate hydratase ERR3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855373, updated on 28-Oct-2024

Summary

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Official Symbol
ERR3
Official Full Name
phosphopyruvate hydratase ERR3
Primary source
SGD:S000004942
Locus tag
YMR323W
See related
AllianceGenome:SGD:S000004942; FungiDB:YMR323W; VEuPathDB:YMR323W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See ERR3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (920088..921401)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene glutathione-independent methylglyoxalase family protein Neighboring gene seripauperin PAU19

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Pryde FE, et al. Yeast, 1995 Apr 15. PMID 7785338
  2. The Saccharomyces cerevisiae enolase-related regions encode proteins that are active enolases. Kornblatt MJ, et al. Yeast, 2013 Feb. PMID 23359425
  3. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
  4. Tritium suicide selection identifies proteins involved in the uptake and intracellular transport of sterols in Saccharomyces cerevisiae. Sullivan DP, et al. Eukaryot Cell, 2009 Feb. PMID 19060182, Free PMC Article
  5. Yeast Ssd1 is a non-enzymatic member of the RNase II family with an alternative RNA recognition site. Bayne RA, et al. Nucleic Acids Res, 2022 Mar 21. PMID 34302485, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphopyruvate hydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphopyruvate hydratase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphopyruvate hydratase ERR3
NP_014056.3
  • Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant in glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    920088..921401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182836.3 → NP_014056.3  TPA: phosphopyruvate hydratase ERR3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014056.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0F0, P42222
    UniProtKB/TrEMBL
    A6ZLP5, A6ZVX7
    Conserved Domains (1) summary
    PTZ00081
    Location:1 → 428
    PTZ00081; enolase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42222.2

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