PHA2 prephenate dehydratase PHA2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHA2
Official Full Name: prephenate dehydratase PHA2
Primary source: SGD:S000005260
Locus tag: YNL316C
See related: AllianceGenome:SGD:S000005260; FungiDB:YNL316C; VEuPathDB:YNL316C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables prephenate dehydratase activity. Involved in L-phenylalanine biosynthetic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PHA2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (42071..43075, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chorismate mutase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prephenate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in L-phenylalanine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-phenylalanine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-phenylalanine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carboxylic acid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prephenate dehydratase PHA2

NP_014083.2

EC 4.2.1.51

Prephenate dehydratase; catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

42071..43075 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183154.1 → NP_014083.2 TPA: prephenate dehydratase PHA2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014083.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0M9, P32452

UniProtKB/TrEMBL

G2WLF3, N1NXB5

Conserved Domains (1) summary

COG0077
Location:4 → 332

PheA2; Prephenate dehydratase [Amino acid transport and metabolism]