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STB1 Stb1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855407, updated on 2-Nov-2024

Summary

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Official Symbol
STB1
Official Full Name
Stb1p
Primary source
SGD:S000005253
Locus tag
YNL309W
See related
AllianceGenome:SGD:S000005253; FungiDB:YNL309W; VEuPathDB:YNL309W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transcription coactivator activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of mating type switching; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of MBF transcription complex; SBF transcription complex; and Sin3-type complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See STB1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (52662..53924)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative SCF ubiquitin ligase complex subunit SKP2 Neighboring gene Zim17p Neighboring gene Kri1p Neighboring gene serine/threonine/tyrosine protein kinase MCK1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network. Stephan OOH. FEMS Yeast Res, 2022 Jan 28. PMID 34905017
  2. A large protein complex containing the yeast Sin3p and Rpd3p transcriptional regulators. Kasten MM, et al. Mol Cell Biol, 1997 Aug. PMID 9234741, Free PMC Article
  3. The cell-cycle transcriptional network generates and transmits a pulse of transcription once each cell cycle. Cho CY, et al. Cell Cycle, 2019 Feb. PMID 30668223, Free PMC Article
  4. Competition in the chaperone-client network subordinates cell-cycle entry to growth and stress. Moreno DF, et al. Life Sci Alliance, 2019 Apr. PMID 30988162, Free PMC Article
  5. G1 transcription factors are differentially regulated in Saccharomyces cerevisiae by the Swi6-binding protein Stb1. Costanzo M, et al. Mol Cell Biol, 2003 Jul. PMID 12832490, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
    Title: Interactions, structural aspects and evolutionary perspectives of the yeast 'START'-regulatory network.
  2. Cln3 regulates SBF by at least two different pathways, one involving the repressive protein Whi5, and the second involving Stb1.
    Title: Recruitment of Cln3 cyclin to promoters controls cell cycle entry via histone deacetylase and other targets.
  3. Chromatin immunoprecipitation experiments show that SBF, Whi5 and Stb1 recruit both Cdc28 and the Rpd3(L) histone deacetylase to G1 cyclin promoters.
    Title: The E2F functional analogue SBF recruits the Rpd3(L) HDAC, via Whi5 and Stb1, and the FACT chromatin reorganizer, to yeast G1 cyclin promoters.
  4. Results show that Stb1 is a stable component of both SBF and MBF that binds G(1)-specific promoters via Swi6 during G(1) phase.
    Title: Stb1 collaborates with other regulators to modulate the G1-specific transcriptional circuit.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transcription coactivator activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mating type switching IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of MBF transcription complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SBF transcription complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Stb1p
NP_014090.2
  • Protein with role in regulation of MBF-specific transcription at Start; phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p, which is required for Stb1p function; expression is cell-cycle regulated; STB1 has a paralog, YOL131W, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    52662..53924
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183147.1 → NP_014090.2  TPA: Stb1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014090.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0N6, P42845
    UniProtKB/TrEMBL
    A6ZSH1, C8ZGL5, G2WLG0, N1NXX7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42845.2

Gene LinkOut

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