YPT11 Rab family GTPase YPT11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YPT11
Official Full Name: Rab family GTPase YPT11
Primary source: SGD:S000005248
Locus tag: YNL304W
See related: AllianceGenome:SGD:S000005248; FungiDB:YNL304W; VEuPathDB:YNL304W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable GTPase activity. Involved in Golgi localization and organelle inheritance. Located in several cellular components, including cellular bud neck; cellular bud tip; and mitochondrion. Part of incipient cellular bud site. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YPT11 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (60297..61550)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The abundance of active Ypt11 forms is controlled by phosphorylation status and degradation.
Title: Mitochondrial association, protein phosphorylation, and degradation regulate the availability of the active Rab GTPase Ypt11 for mitochondrial inheritance.
Myo2 drives anterograde mitochondrial movements in budding yeast and this activity is supported by Ypt11 and Mmr1.
Title: The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.
required for the vectorial actin-dependent movement of the late Golgi from the mother cell toward the emerging bud
Title: Ypt11 functions in bud-directed transport of the Golgi by linking Myo2 to the coatomer subunit Ret2.
These findings provide insight into novel gene functions and classify the uncharacterized Rab proteins Ypt10p (YBR264C) as being involved in endocytic function and Ypt11p (YNL304W) as being localized to the endoplasmic reticulum.
Title: Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p.
retention of mitochondria in the bud was compromised in YPT11 and MYO2 mutants
Title: A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.
we show that, in human cells, after heterologous expression of GFP-Ypt11 (where GFP stands for green fluorescent protein), the protein is targeted to transferrin-positive recycling endosomes.
Title: Yeast Ypt11 is targeted to recycling endosomes in mammalian cells.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISA Inferred from Sequence Alignment more info	PubMed
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi distribution to daughter cells	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi distribution to daughter cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Golgi inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Golgi inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum inheritance	IDA Inferred from Direct Assay more info	PubMed
involved_in endoplasmic reticulum inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular distribution of mitochondria	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular distribution of mitochondria	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrion inheritance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud tip	IDA Inferred from Direct Assay more info	PubMed
located_in cellular bud tip	IEA Inferred from Electronic Annotation more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Rab family GTPase YPT11

NP_014095.2

Rab GTPase; Myo2p-binding protein implicated in mother-to-bud transport of cortical endoplasmic reticulum (ER), late Golgi, and mitochondria during cell division; function is regulated at multiple levels; abundance of active Ypt11p forms is controlled by phosphorylation status and degradation; normally a low-abundance protein whose ER localization is only detected when protein is highly over expressed

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

60297..61550

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183142.1 → NP_014095.2 TPA: Rab family GTPase YPT11 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014095.2

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZSH6, B5VQB6, D6W0P1, P48559

UniProtKB/TrEMBL

C7GWQ1, G2WLG5, N1P4J4

Conserved Domains (1) summary

cd00154
Location:196 → 331

Rab; Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases)