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MON2 Mon2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855420, updated on 2-Nov-2024

Summary

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Official Symbol
MON2
Official Full Name
Mon2p
Primary source
SGD:S000005241
Locus tag
YNL297C
See related
AllianceGenome:SGD:S000005241; FungiDB:YNL297C; VEuPathDB:YNL297C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YSL2
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in endocytosis; protein targeting to vacuole; and retrograde transport, endosome to Golgi. Located in early endosome membrane and trans-Golgi network. Orthologous to human MON2 (MON2 homolog, regulator of endosome-to-Golgi trafficking). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MON2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (71673..76583, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene non-canonical poly(A) polymerase TRF5 Neighboring gene serine/threonine protein kinase CLA4 Neighboring gene Mrx6p Neighboring gene Rim21p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast Ysl2p, homologous to Sec7 domain guanine nucleotide exchange factors, functions in endocytosis and maintenance of vacuole integrity and interacts with the Arf-Like small GTPase Arl1p. Jochum A, et al. Mol Cell Biol, 2002 Jul. PMID 12052896, Free PMC Article
  2. Molecular interactions of yeast Neo1p, an essential member of the Drs2 family of aminophospholipid translocases, and its role in membrane trafficking within the endomembrane system. Wicky S, et al. Mol Cell Biol, 2004 Sep. PMID 15314152, Free PMC Article
  3. Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis. Efe JA, et al. J Cell Sci, 2005 Oct 15. PMID 16219684
  4. Mon2 is a negative regulator of the monomeric G protein, Arl1. Manlandro CM, et al. FEMS Yeast Res, 2012 Sep. PMID 22594927
  5. Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex. Barbosa S, et al. Traffic, 2010 Aug. PMID 20477991

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors demonstrated that MON2 is a negative regulator of the GTP-restricted allele of ARL1 , ARL1[Q72L].
    Title: Mon2 is a negative regulator of the monomeric G protein, Arl1.
  2. Data show that Dop1p localizes to endosomes and exists in a complex with Neo1p-Ysl2p-Arl1p.
    Title: Oligomeric Dop1p is part of the endosomal Neo1p-Ysl2p-Arl1p membrane remodeling complex.
  3. Ysl2p represents an essential, evolutionarily conserved member of a network controlling direct binding and membrane docking of Ggas..
    Title: Yeast and human Ysl2p/hMon2 interact with Gga adaptors and mediate their subcellular distribution.
  4. Mon2p is a scaffold protein with novel conserved domains, and is involved in multiple aspects of endomembrane trafficking.
    Title: Yeast Mon2p is a highly conserved protein that functions in the cytoplasm-to-vacuole transport pathway and is required for Golgi homeostasis.
  5. Dop1 plays a widespread role in membrane organization, and Mon2 acts as a scaffold to recruit the Golgi-localized pool of Dop1
    Title: Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to vacuole HMP PubMed 
involved_in protein targeting to vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mon2p
NP_014102.1
  • Protein with a role in endocytosis and vacuole integrity; peripheral membrane protein; interacts with and negatively regulates Arl1p; localizes to the endosome; member of the Sec7p family of proteins

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    71673..76583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183135.1 → NP_014102.1  TPA: Mon2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014102.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P7, P48563
    UniProtKB/TrEMBL
    A6ZSI2, B5VQC1, C7GS58, N1NZQ9
    Conserved Domains (3) summary
    pfam16206
    Location:936 → 1161
    Mon2_C; C-terminal region of Mon2 protein
    pfam12783
    Location:202 → 362
    Sec7_N; Guanine nucleotide exchange factor in Golgi transport N-terminal
    pfam16213
    Location:8 → 176
    DCB; dimerization and cyclophilin-binding domain of Mon2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48563.1

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