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MRX6 Mrx6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855421, updated on 2-Nov-2024

Summary

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Official Symbol
MRX6
Official Full Name
Mrx6p
Primary source
SGD:S000005239
Locus tag
YNL295W
See related
AllianceGenome:SGD:S000005239; FungiDB:YNL295W; VEuPathDB:YNL295W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial nucleoid organization and regulation of mitochondrial DNA metabolic process. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MRX6 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (76946..78520)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene serine/threonine protein kinase CLA4 Neighboring gene Mon2p Neighboring gene Rim21p Neighboring gene Rab GTPase-activating protein MSB3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1. Göke A, et al. Mol Biol Cell, 2020 Mar 19. PMID 31532710, Free PMC Article
  2. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
  3. The yeast protein Mam33 functions in the assembly of the mitochondrial ribosome. Hillman GA, et al. J Biol Chem, 2019 Jun 21. PMID 31053642, Free PMC Article
  4. Genomewide screen reveals a wide regulatory network for di/tripeptide utilization in Saccharomyces cerevisiae. Cai H, et al. Genetics, 2006 Mar. PMID 16361226, Free PMC Article
  5. Molecular Connectivity of Mitochondrial Gene Expression and OXPHOS Biogenesis. Singh AP, et al. Mol Cell, 2020 Sep 17. PMID 32877643

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial nucleoid organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitochondrial DNA metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mrx6p
NP_014104.1
  • Mitochondrial ribosome-associated protein; regulates mitochondrial DNA copy number and the size and distribution of mtDNA nucleoids; subunit of a complex containing Pet20p, Mam33p, and Pim1p that may regulate mtDNA replication; member of the PET20 domain-containing protein family; forms foci that partially co-localize with mtDNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    76946..78520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183133.1 → NP_014104.1  TPA: Mrx6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014104.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0P8, P48564
    UniProtKB/TrEMBL
    A6ZSI3, C7GS57
    Conserved Domains (1) summary
    pfam08692
    Location:111 → 242
    Pet20; Mitochondrial protein Pet20
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48564.1

Gene LinkOut

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