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RFC3 replication factor C subunit 3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855426, updated on 2-Nov-2024

Summary

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Official Symbol
RFC3
Official Full Name
replication factor C subunit 3
Primary source
SGD:S000005234
Locus tag
YNL290W
See related
AllianceGenome:SGD:S000005234; FungiDB:YNL290W; VEuPathDB:YNL290W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ATP hydrolysis activity. Contributes to DNA clamp loader activity. Involved in leading strand elongation. Located in cytosol and nucleus. Part of chromosome. Orthologous to human RFC5 (replication factor C subunit 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See RFC3 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (86218..87240)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene pseudouridine synthase PUS4 Neighboring gene Mid1p Neighboring gene Pcl1p Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and expression of the Saccharomyces cerevisiae RFC3 gene, an essential component of replication factor C. Li X, et al. Proc Natl Acad Sci U S A, 1994 Feb 1. PMID 8302859, Free PMC Article
  2. The Schizosaccharomyces pombe rfc3+ gene encodes a homologue of the human hRFC36 and Saccharomyces cerevisiae Rfc3 subunits of replication factor C. Gray FC, et al. Curr Genet, 2000 Mar. PMID 10794172
  3. Cloning and characterization of the essential Saccharomyces cerevisiae RFC4 gene encoding the 37-kDa subunit of replication factor C. Li X, et al. J Biol Chem, 1994 Aug 26. PMID 8063832
  4. Dominant mutations in three different subunits of replication factor C suppress replication defects in yeast PCNA mutants. Amin NS, et al. Genetics, 1999 Dec. PMID 10581271, Free PMC Article
  5. Eukaryotic DNA mismatch repair. Kolodner RD, et al. Curr Opin Genet Dev, 1999 Feb. PMID 10072354

See all (109) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA clamp loader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to DNA clamp loader activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA clamp unloading IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand elongation involved in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in leading strand elongation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mismatch repair TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Ctf18 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ctf18 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of DNA replication factor C complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication factor C complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Elg1 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Elg1 RFC-like complex IEA
Inferred from Electronic Annotation
more info
  
part_of Elg1 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of Rad17 RFC-like complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rad17 RFC-like complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rad17 RFC-like complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication factor C subunit 3
NP_014109.1
  • Subunit of heteropentameric Replication factor C (RF-C); which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    86218..87240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183128.1 → NP_014109.1  TPA: replication factor C subunit 3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014109.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Q3, P38629
    UniProtKB/TrEMBL
    A6ZSI8, B3LPC8, C7GS53, C8ZGN1, G2WLH7, N1NXW7
    Conserved Domains (1) summary
    PRK00440
    Location:11 → 324
    rfc; replication factor C small subunit; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38629.1

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