PCL1 Pcl1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PCL1
Official Full Name: Pcl1p
Primary source: SGD:S000005233
Locus tag: YNL289W
See related: AllianceGenome:SGD:S000005233; FungiDB:YNL289W; VEuPathDB:YNL289W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HCS26
Summary: Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including positive regulation of macroautophagy; regulation of cyclin-dependent protein serine/threonine kinase activity; and septin ring organization. Located in nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and incipient cellular bud site. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
involved_in regulation of establishment or maintenance of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment or maintenance of cell polarity	IPI Inferred from Physical Interaction more info	PubMed
involved_in septin ring organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IEA Inferred from Electronic Annotation more info
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in incipient cellular bud site	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014110.1

Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; is ubiquitinated by Dma1p; phosphorylation by Pho85p targets it for degradation; localizes to sites of polarized cell growth

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The following sections contain reference sequences that belong to a specific genome build. Explain