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WSC2 Wsc2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855438, updated on 28-Oct-2024

Summary

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Official Symbol
WSC2
Official Full Name
Wsc2p
Primary source
SGD:S000005227
Locus tag
YNL283C
See related
AllianceGenome:SGD:S000005227; FungiDB:YNL283C; VEuPathDB:YNL283C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
STA3
Summary
Enables transmembrane signaling receptor activity. Involved in Rho protein signal transduction; fungal-type cell wall organization; and response to heat. Located in cellular bud neck and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See WSC2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (105184..106695, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL10/YmL18 Neighboring gene tRNA-Thr Neighboring gene Pop3p Neighboring gene Hch1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo. Wilk S, et al. Mol Genet Genomics, 2010 Sep. PMID 20652590
  2. The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase. de la Fuente N, et al. Biochim Biophys Acta, 2000 Dec 20. PMID 11118530
  3. Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Lodder AL, et al. Genetics, 1999 Aug. PMID 10430578, Free PMC Article
  4. Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Raboy B, et al. Mol Microbiol, 1999 May. PMID 10361277
  5. Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Rajavel M, et al. Mol Cell Biol, 1999 Jun. PMID 10330137, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
    Title: Protein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in Saccharomyces cerevisiae.
  2. Data show that Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).
    Title: A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
  
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in mating projection tip HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in site of polarized growth IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Wsc2p
NP_014116.1
  • Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    105184..106695 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183121.1 → NP_014116.1  TPA: Wsc2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014116.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R1, P53832
    UniProtKB/TrEMBL
    A6ZRG2, C8ZGN8, G2WLI3, N1P4Y1
    Conserved Domains (1) summary
    smart00321
    Location:25 → 118
    WSC; present in yeast cell wall integrity and stress response component proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53832.1

Gene LinkOut

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