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POP3 Pop3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855439, updated on 2-Nov-2024

Summary

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Official Symbol
POP3
Official Full Name
Pop3p
Primary source
SGD:S000005226
Locus tag
YNL282W
See related
AllianceGenome:SGD:S000005226; FungiDB:YNL282W; VEuPathDB:YNL282W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See POP3 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (107687..108274)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene tRNA-Thr Neighboring gene Wsc2p Neighboring gene Hch1p Neighboring gene delta(14)-sterol reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An active precursor in assembly of yeast nuclear ribonuclease P. Srisawat C, et al. RNA, 2002 Oct. PMID 12403471, Free PMC Article
  2. Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. Dichtl B, et al. EMBO J, 1997 Jan 15. PMID 9029160, Free PMC Article
  3. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P. Perederina A, et al. RNA Biol, 2023 Jan. PMID 37074161, Free PMC Article
  4. In vitro reconstitution and analysis of eukaryotic RNase P RNPs. Perederina A, et al. Nucleic Acids Res, 2018 Jul 27. PMID 29722866, Free PMC Article
  5. Saccharomyces cerevisiae contains an RNase MRP that cleaves at a conserved mitochondrial RNA sequence implicated in replication priming. Stohl LL, et al. Mol Cell Biol, 1992 Jun. PMID 1588958, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
    Title: Proteins Rpr2 and Pop3 increase the activity and thermal stability of yeast RNase P.
  2. 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p.
    Title: 3D models of yeast RNase P/MRP proteins Rpp1p and Pop3p.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to ribonuclease MRP activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease MRP activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease P activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in intronic box C/D snoRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intronic box C/D snoRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in rRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nucleolar ribonuclease P complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nucleolar ribonuclease P complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonuclease MRP complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonuclease MRP complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Pop3p
NP_014117.1
  • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; increases the activity and thermal stability of the RNase P complex, along with Pop2p; relocalizes to the cytosol in response to hypoxia

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    107687..108274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183120.1 → NP_014117.1  TPA: Pop3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R2, P53833
    UniProtKB/TrEMBL
    A6ZRG3, B3LPC1, B5VQD4, C7GP82, C8ZGN9, G2WLI4, N1NYB7
    Conserved Domains (1) summary
    pfam08228
    Location:14 → 171
    RNase_P_pop3; RNase P subunit Pop3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53833.1

Gene LinkOut

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