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PRM1 pheromone-regulated protein PRM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855442, updated on 2-Nov-2024

Summary

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Official Symbol
PRM1
Official Full Name
pheromone-regulated protein PRM1
Primary source
SGD:S000005223
Locus tag
YNL279W
See related
AllianceGenome:SGD:S000005223; FungiDB:YNL279W; VEuPathDB:YNL279W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in plasma membrane fusion involved in cytogamy. Located in mating projection tip. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PRM1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (110917..112902)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Hch1p Neighboring gene delta(14)-sterol reductase Neighboring gene Caf120p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Prm1 prevents contact-dependent lysis of yeast mating pairs. Jin H, et al. Eukaryot Cell, 2004 Dec. PMID 15590839, Free PMC Article
  2. Prm1 functions as a disulfide-linked complex in yeast mating. Olmo VN, et al. J Biol Chem, 2010 Jan 22. PMID 19933274, Free PMC Article
  3. The yeast cell fusion protein Prm1p requires covalent dimerization to promote membrane fusion. Engel A, et al. PLoS One, 2010 May 11. PMID 20485669, Free PMC Article
  4. The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating. Heiman MG, et al. J Cell Biol, 2007 Jan 15. PMID 17210951, Free PMC Article
  5. Glycosylation abnormalities in Gdt1p/TMEM165 deficient cells result from a defect in Golgi manganese homeostasis. Potelle S, et al. Hum Mol Genet, 2016 Apr 15. PMID 27008884

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cells lacking both ECM22 and UPC2 display strong mating defects whereas deletion of either gene has no effect. Ecm22 and Upc2 positively regulate basal expression of PRM1 and PRM4. These genes are strongly induced in response to mating pheromone, which is also largely dependent on ECM22 and UPC2.
    Title: Ecm22 and Upc2 regulate yeast mating through control of expression of the mating genes PRM1 and PRM4.
  2. Cys(120) in loop 1 and Cys(545) in loop 2 form disulfide cross-links in the Prm1 homodimer and are required for fusion activity
    Title: Prm1 functions as a disulfide-linked complex in yeast mating.
  3. Kex2 and Kex1 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both.
    Title: The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
  4. Prm1 protein stabilizes the membrane fusion event of yeast mating
    Title: Prm1 prevents contact-dependent lysis of yeast mating pairs.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in plasma membrane fusion involved in cytogamy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in plasma membrane fusion involved in cytogamy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole HDA PubMed 
is_active_in mating projection tip IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mating projection tip IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mating projection tip IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pheromone-regulated protein PRM1
NP_014120.1
  • Pheromone-regulated multispanning membrane protein; involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    110917..112902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183117.1 → NP_014120.1  TPA: pheromone-regulated protein PRM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014120.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R5, P53835
    UniProtKB/TrEMBL
    B3LPB8, N1NWX5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53835.1

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