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BOR1 Bor1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855446, updated on 2-Nov-2024

Summary

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Official Symbol
BOR1
Official Full Name
Bor1p
Primary source
SGD:S000005219
Locus tag
YNL275W
See related
AllianceGenome:SGD:S000005219; FungiDB:YNL275W; VEuPathDB:YNL275W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables borate efflux transmembrane transporter activity. Involved in borate transport and protein targeting to vacuole. Located in fungal-type vacuole and plasma membrane. Used to study anemia; hereditary spherocytosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia (multiple); corneal dystrophy-perceptive deafness syndrome; corneal endothelial dystrophy (multiple); osteopetrosis; and renal tubular acidosis. Orthologous to several human genes including SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See BOR1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (119268..120998)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene homoserine O-acetyltransferase Neighboring gene glyoxylate reductase Neighboring gene Tof1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Boron-dependent regulation of translation through AUGUAA sequence in yeast. Tsednee M, et al. Yeast, 2020 Dec. PMID 33289202
  2. Protein-Lipid Interactions Stabilize the Oligomeric State of BOR1p from Saccharomyces cerevisiae. Pyle E, et al. Anal Chem, 2019 Oct 15. PMID 31513392
  3. Structure of the SLC4 transporter Bor1p in an inward-facing conformation. Coudray N, et al. Protein Sci, 2017 Jan. PMID 27717063, Free PMC Article
  4. Isolation of Arabidopsis thaliana cDNAs that confer yeast boric acid tolerance. Nozawa A, et al. Biosci Biotechnol Biochem, 2006 Jul. PMID 16861809
  5. Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance. Takano J, et al. FEMS Microbiol Lett, 2007 Feb. PMID 17166224

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structural and functional insights into the mechanism of action of plant borate transporters.
    Title: Structural and functional insights into the mechanism of action of plant borate transporters.
  2. Unlikely that the main function of Bor1 is boron efflux, but may have role in vacuolar dynamics.
    Title: Transport and regulatory characteristics of the yeast bicarbonate transporter homolog Bor1p.
  3. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration.
    Title: Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae.
  4. Bor1p is a plasma membrane boron exporter and a key determinant of boron tolerance.
    Title: Saccharomyces cerevisiae Bor1p is a boron exporter and a key determinant of boron tolerance.
  5. enolase stimulates vacuole fusion and enolase and Bor1p regulate selective protein trafficking to the vacuole
    Title: Enolase activates homotypic vacuole fusion and protein transport to the vacuole in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables borate efflux transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables borate efflux transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables borate efflux transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in borate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in borate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in borate transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in borate transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein targeting to vacuole IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in fungal-type vacuole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bor1p
NP_014124.1
  • Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    119268..120998
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183113.1 → NP_014124.1  TPA: Bor1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014124.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0R9, P53838
    UniProtKB/TrEMBL
    A6ZRG9, B3LPB4, B5VQD9, C7GP88, C8ZGP7, G2WLJ1
    Conserved Domains (1) summary
    cl23746
    Location:61 → 475
    Xan_ur_permease; Permease family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53838.1

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