PIK1 1-phosphatidylinositol 4-kinase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PIK1
Official Full Name: 1-phosphatidylinositol 4-kinase
Primary source: SGD:S000005211
Locus tag: YNL267W
See related: AllianceGenome:SGD:S000005211; FungiDB:YNL267W; VEuPathDB:YNL267W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PIK120; PIK41
Summary: Enables 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including microlipophagy; phosphatidylinositol phosphate biosynthetic process; and positive regulation of autophagosome assembly. Located in nucleus and trans-Golgi network. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See PIK1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (140878..144078)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling.
Title: A type II phosphatidylinositol-4-kinase coordinates sorting of cargo polarizing by endocytic recycling.
Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
Title: Microautophagy in the yeast vacuole depends on the activities of phosphatidylinositol 4-kinases, Stt4p and Pik1p.
Pik1 plays essential roles in autophagosome formation.
Title: Essential and distinct roles of phosphatidylinositol 4-kinases, Pik1p and Stt4p, in yeast autophagy.
Inhibition of Gga2-Pik1 binding resulted in reduced Pik1 localization and delayed accumulation of phosphatidylinositol 4-phosphate to the trans-Golgi network.
Title: Conserved role for Gga proteins in phosphatidylinositol 4-kinase localization to the trans-Golgi network.
Thus, our results suggest that pik1(+) is required for the maintenance of circular chromosomes.
Title: Mutation in fission yeast phosphatidylinositol 4-kinase Pik1 is synthetically lethal with defect in telomere protection protein Pot1.
Data show the PtdIns 4-kinase Pik1 is involved in Atg9 trafficking through the Golgi and is involved in both nonselective and selective types of autophagy, whereas the PtdIns4P 5-kinase Mss4 is involved in mitophagy but not nonselective autophagy.
Title: Phosphatidylinositol 4-kinases are required for autophagic membrane trafficking.
Data show that Gga2p binds directly to the Gga2p binds directly to the trans-Golgi network (TGN) PtdIns(4)-kinase Pik1p and contributes to Pik1p recruitment.
Title: Phosphoinositide-mediated clathrin adaptor progression at the trans-Golgi network.
Nucleocytoplasmic shuttling of Pik1p involves phosphorylation and 14-3-3 proteins bind Pik1p in the cytoplasm.
Title: Nucleocytoplasmic shuttling of the Golgi phosphatidylinositol 4-kinase Pik1 is regulated by 14-3-3 proteins and coordinates Golgi function with cell growth.
analysis of growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase
Title: Growth control of Golgi phosphoinositides by reciprocal localization of sac1 lipid phosphatase and pik1 4-kinase.
results suggest that Pik1p and the Sjl proteins coordinately function to regulate the dynamic phosphorylation-dephosphorylation of the polar heads of phosphoinositides, and this process appears to be important for membrane trafficking pathways
Title: Interaction of Pik1p and Sjl proteins in membrane trafficking.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol 4-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol 4-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol 4-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol 4-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphotransferase activity, alcohol group as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to nitrogen starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to stress	IEA Inferred from Electronic Annotation more info
involved_in microlipophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of autophagosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: 1-phosphatidylinositol 4-kinase

NP_014132.1

EC 2.7.1.67

Phosphatidylinositol 4-kinase; catalyzes the first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton; required for autophagosome formation during autophagy and for lipophagy in both stationary phase cells and during nitrogen starvation; may control nonselective autophagy and mitophagy through trafficking of Atg9p; localizes to the nucleus and to the trans-Golgi network

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

140878..144078

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183105.1 → NP_014132.1 TPA: 1-phosphatidylinositol 4-kinase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014132.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0S7, P39104

UniProtKB/TrEMBL

B3LPA6, C8ZFX2

Conserved Domains (1) summary

COG5032
Location:1 → 1066

TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]