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LTO1 ribosome biosynthesis protein LTO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855461, updated on 28-Oct-2024

Summary

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Official Symbol
LTO1
Official Full Name
ribosome biosynthesis protein LTO1
Primary source
SGD:S000005204
Locus tag
YNL260C
See related
AllianceGenome:SGD:S000005204; FungiDB:YNL260C; VEuPathDB:YNL260C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to protein-macromolecule adaptor activity. Involved in protein maturation by [4Fe-4S] cluster transfer. Located in nucleus. Part of Yae1-Lto1 complex. [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See LTO1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (156859..157347, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon catalytic subunit Neighboring gene origin recognition complex subunit 5 Neighboring gene copper metallochaperone ATX1 Neighboring gene Dsl1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation. Heuer A, et al. Nat Struct Mol Biol, 2017 May. PMID 28368393
  2. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Sen-Gupta M, et al. Yeast, 1997 Jul. PMID 9234673
  3. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279
  4. The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: essential roles in the function and biogenesis of the ribosome. Zhai C, et al. Oncogene, 2014 Jan 23. PMID 23318452
  5. Large-scale analysis of yeast filamentous growth by systematic gene disruption and overexpression. Jin R, et al. Mol Biol Cell, 2008 Jan. PMID 17989363, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, the Yae1-Lto1 complex functions as a target-specific adaptor that recruits apo-Rli1 to the generic cytosolic iron-sulfur assembly machinery.
    Title: The deca-GX3 proteins Yae1-Lto1 function as adaptors recruiting the ABC protein Rli1 for iron-sulfur cluster insertion.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to protein-macromolecule adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation by [4Fe-4S] cluster transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Yae1-Lto1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Yae1-Lto1 complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosome biosynthesis protein LTO1
NP_014139.2
  • Substrate-specific adaptor protein involved in apo-Rli1p maturation; subunit of the Yae1-Lto1 complex, recruiting apo-Rli1p to the CIA targeting complex, facilitating the insertion of an Fe/S cluster by the Fe-S biosynthetic machinery; deca-GX3 motif crucial for complex formation; essential for aerobic but not anaerobic growth; homolog of human ORAOV1, which is overexpressed in solid tumors; co-expression of ORAOV1 and YAE1 homolog YAE1D1 restores growth and Rli1p maturation after LTO1 depletion

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    156859..157347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183098.2 → NP_014139.2  TPA: ribosome biosynthesis protein LTO1 [Saccharomyces cerevisiae S288C]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0T3, P53846
    UniProtKB/TrEMBL
    A6ZRI3, B5VQF1, G2WLK6, N1NZX8
    Conserved Domains (2) summary
    COG3587
    Location:70 → 161
    COG3587; Restriction endonuclease [Defense mechanisms]
    pfam09811
    Location:17 → 55
    Yae1_N; Essential protein Yae1, N terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53846.2

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