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GIS2 mRNA-binding translational activator GIS2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855466, updated on 28-Oct-2024

Summary

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Official Symbol
GIS2
Official Full Name
mRNA-binding translational activator GIS2
Primary source
SGD:S000005199
Locus tag
YNL255C
See related
AllianceGenome:SGD:S000005199; FungiDB:YNL255C; VEuPathDB:YNL255C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity; single-stranded DNA binding activity; and translation regulator activity. Involved in positive regulation of cytoplasmic translation. Located in P-body and cytoplasmic stress granule. Used to study myotonic dystrophy type 2. Human ortholog(s) of this gene implicated in myotonic dystrophy type 2. Orthologous to several human genes including ZCCHC13 (zinc finger CCHC-type containing 13). [provided by Alliance of Genome Resources, Oct 2024]
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Genomic context

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See GIS2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (167329..167790, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sip3p Neighboring gene trifunctional dihydropteroate synthetase/dihydrohydroxymethylpterin pyrophosphokinase/dihydroneopterin aldolase FOL1 Neighboring gene Rtc4p Neighboring gene Tex1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S phase block following MEC1ATR inactivation occurs without severe dNTP depletion. Earp C, et al. Biol Open, 2015 Nov 24. PMID 26603472, Free PMC Article
  2. The GIS2 Gene Is Repressed by a Zinc-Regulated Bicistronic RNA in Saccharomyces cerevisiae. Taggart J, et al. Genes (Basel), 2018 Sep 19. PMID 30235899, Free PMC Article
  3. Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules. Rojas M, et al. PLoS One, 2012. PMID 23285195, Free PMC Article
  4. The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. Tsvetanova NG, et al. PLoS Genet, 2012. PMID 22844259, Free PMC Article
  5. Sequence analysis of the 33 kb long region between ORC5 and SUI1 from the left arm of chromosome XIV from Saccharomyces cerevisiae. Sen-Gupta M, et al. Yeast, 1997 Jul. PMID 9234673

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gis2 is a component of two large RNA-protein granules, processing bodies and stress granules, which contain translationally repressed mRNAs.
    Title: Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules.
  2. These data suggest that Gis2 is functionally orthologous to ZNF9 and acts as a cap-independent translation factor.
    Title: Saccharomyces cerevisiae Gis2 interacts with the translation machinery and is orthogonal to myotonic dystrophy type 2 protein ZNF9.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in P-body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mRNA-binding translational activator GIS2
NP_014144.1
  • Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    167329..167790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183093.1 → NP_014144.1  TPA: mRNA-binding translational activator GIS2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014144.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0T8, P53849
    UniProtKB/TrEMBL
    A6ZRI8, B3LP98, C7GPA6, C8ZFY2, G2WLL1, N1NZY3
    Conserved Domains (1) summary
    COG5082
    Location:1 → 129
    AIR1; Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53849.1

Gene LinkOut

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