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ZWF1 glucose-6-phosphate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855480, updated on 9-Jun-2024

Summary

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Gene symbol
ZWF1
Gene description
glucose-6-phosphate dehydrogenase
Primary source
FungiDB:YNL241C
Locus tag
YNL241C
See related
SGD:S000005185; AllianceGenome:SGD:S000005185; VEuPathDB:YNL241C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MET19; POS10
Summary
Enables glucose-6-phosphate dehydrogenase activity. Involved in pentose-phosphate shunt, oxidative branch and response to hydrogen peroxide. Located in cytoplasm. Used to study congenital nonspherocytic hemolytic anemia. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cortisone reductase deficiency (multiple); favism; malaria (multiple); and neonatal jaundice. Orthologous to several human genes including G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ZWF1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (196426..197943, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Sla2p Neighboring gene Atg2p Neighboring gene iron-sulfur cluster assembly protein NAR1 Neighboring gene bleomycin hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tailoring strain construction strategies for muconic acid production in S. cerevisiae and E. coli. Averesch NJH, et al. Metab Eng Commun, 2014 Dec. PMID 34150501, Free PMC Article
  2. Bidirectional titration of yeast gene expression using a pooled CRISPR guide RNA approach. Bowman EK, et al. Proc Natl Acad Sci U S A, 2020 Aug 4. PMID 32690674, Free PMC Article
  3. Investigation of Heterologously Expressed Glucose-6-Phosphate Dehydrogenase Genes in a Yeast zwf1 Deletion. Heinisch JJ, et al. Microorganisms, 2020 Apr 9. PMID 32283834, Free PMC Article
  4. Protein expression analysis revealed a fine-tuned mechanism of in situ detoxification pathway for the tolerant industrial yeast Saccharomyces cerevisiae. Liu ZL, et al. Appl Microbiol Biotechnol, 2019 Jul. PMID 31139900
  5. Importance of glucose-6-phosphate dehydrogenase (G6PDH) for vanillin tolerance in Saccharomyces cerevisiae. Nguyen TT, et al. J Biosci Bioeng, 2014 Sep. PMID 24725964

See all (129) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
    Title: Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production.
  2. Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
    Title: Screening of selected ageing-related proteins that extend chronological life span in yeast Saccharomyces cerevisiae.
  3. An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
    Title: An NADPH-independent mechanism enhances oxidative and nitrosative stress tolerance in yeast cells lacking glucose-6-phosphate dehydrogenase activity.
  4. Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depot structures.
    Title: Glucose 6-phosphate and alcohol dehydrogenase activities are components of dynamic macromolecular depots structures.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucose-6-phosphate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADPH regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pentose-phosphate shunt, oxidative branch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glucose-6-phosphate dehydrogenase
NP_014158.1
  • Glucose-6-phosphate dehydrogenase (G6PD); catalyzes the first step of the pentose phosphate pathway; involved in adaptation to oxidative stress; negative regulator of nonselective autophagy, independent of Stb5p; protein abundance increases in response to DNA replication stress; homolog of human G6PD which is deficient in patients with hemolytic anemia; human G6PD can complement yeast zwf1 null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    196426..197943 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183079.1 → NP_014158.1  TPA: glucose-6-phosphate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014158.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0V2, E9P908, P11412
    UniProtKB/TrEMBL
    A0A8H4BXM1, A6ZRK2, B3LP80, B5VQG8, G2WLM5, N1NZZ8
    Conserved Domains (1) summary
    TIGR00871
    Location:10 → 489
    zwf; glucose-6-phosphate 1-dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11412.4

Gene LinkOut

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