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IES2 Ies2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855506, updated on 2-Nov-2024

Summary

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Official Symbol
IES2
Official Full Name
Ies2p
Primary source
SGD:S000005159
Locus tag
YNL215W
See related
AllianceGenome:SGD:S000005159; FungiDB:YNL215W; VEuPathDB:YNL215W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable DNA binding activity. Predicted to be involved in DNA repair and chromatin remodeling. Located in nucleus. Part of Ino80 complex. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See IES2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (244468..245430)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative serine/threonine-protein phosphatase Neighboring gene DNA-binding transcription factor RAP1 Neighboring gene Pex17p Neighboring gene Rrg9p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dosage of chromatin proteins affects transcriptional silencing and DNA repair in Saccharomyces cerevisiae. Benbow SZ, et al. FEBS Lett, 2008 Feb 20. PMID 18211810
  2. DNA repair defects ascribed to pby1 are caused by disruption of Holliday junction resolvase Mus81-Mms4. Ölmezer G, et al. DNA Repair (Amst), 2015 Sep. PMID 26068713
  3. Disruption and basic phenotypic analysis of 18 novel genes from the yeast Saccharomyces cerevisiae. Wysocki R, et al. Yeast, 1999 Jan 30. PMID 10029995
  4. The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres. Chambers AL, et al. Genes Dev, 2012 Dec 1. PMID 23207916, Free PMC Article
  5. Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome. Snoek IS, et al. FEMS Yeast Res, 2006 May. PMID 16630279

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Ino80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ino80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ino80 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ies2p
NP_014184.1
  • Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    244468..245430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183053.1 → NP_014184.1  TPA: Ies2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014184.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0X5, P40154
    UniProtKB/TrEMBL
    A6ZRM5, B3LP59, B5VQJ7, C7GPE2, G2WLP8, N1NZ65
    Conserved Domains (1) summary
    pfam04795
    Location:237 → 297
    PAPA-1; PAPA-1-like conserved region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40154.1

Gene LinkOut

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