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MER1 Mer1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855511, updated on 2-Nov-2024

Summary

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Official Symbol
MER1
Official Full Name
Mer1p
Primary source
SGD:S000005154
Locus tag
YNL210W
See related
AllianceGenome:SGD:S000005154; FungiDB:YNL210W; VEuPathDB:YNL210W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables U1 snRNP binding activity and mRNA binding activity. Involved in positive regulation of mRNA splicing, via spliceosome and reciprocal meiotic recombination. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See MER1 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (250931..251743)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Vid27p Neighboring gene Mrx7p Neighboring gene Hsp70 family ATPase SSB2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast mer1 mutants display reduced levels of meiotic recombination. Engebrecht J, et al. Genetics, 1989 Feb. PMID 2659434, Free PMC Article
  2. MER1, a yeast gene required for chromosome pairing and genetic recombination, is induced in meiosis. Engebrecht J, et al. Mol Cell Biol, 1990 May. PMID 2183032, Free PMC Article
  3. A subset of Mer1p-dependent introns requires Bud13p for splicing activation and nuclear retention. Scherrer FW Jr, et al. RNA, 2006 Jul. PMID 16738408, Free PMC Article
  4. Binding of a cell-type-specific RNA splicing factor to its target regulatory sequence. Nandabalan K, et al. Mol Cell Biol, 1995 Apr. PMID 7891689, Free PMC Article
  5. Meiotic gene conversion and crossing over: their relationship to each other and to chromosome synapsis and segregation. Engebrecht J, et al. Cell, 1990 Sep 7. PMID 2203538

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snu56p links pre-mRNA-bound Mer1p to Nam8p in the U1 snRNP
    Title: Snu56p is required for Mer1p-activated meiotic splicing.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mer1p
NP_014189.1
  • mRNA-binding protein required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    250931..251743
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183048.1 → NP_014189.1  TPA: Mer1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014189.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0Y0, P16523
    UniProtKB/TrEMBL
    A6ZRN0, B3LP54, B5VQK2, C7GPE7, C8ZG22, G2WLQ3, N1NX94
    Conserved Domains (1) summary
    cl00098
    Location:188 → 263
    KH-I; K homology (KH) RNA-binding domain, type I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16523.1

Gene LinkOut

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